Gipc1 - GIPC PDZ domain containing family, member 1 Gene

Also Known as Gipc; Rgs19; Rgs19ip1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 83823

Summary

Enables PDZ domain binding activity. Predicted to be involved in several processes, including negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of melanin biosynthetic process; and positive regulation of transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within several processes, including cellular response to interleukin-7; endothelial cell migration; and glutamate secretion. Located in several cellular components, including brush border; cytosol; and endocytic vesicle. Orthologous to human GIPC1 (GIPC PDZ domain containing family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Gipc1 Products (1)

mRNA	Protein	Name
NM_053341.3	NP_445793.1	PDZ domain-containing protein GIPC1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	14617818	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	14617818	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	16819522	RGD
located in brush border	IDA IDA: Inferred from direct assay	11912251	RGD
located in endocytic vesicle	IDA IDA: Inferred from direct assay	14617818	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	16819522	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	16819522	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
PDZ domain-containing protein GIPC1	GAIP C-terminus-interacting protein GLUT1 C-terminal-binding protein GLUT1CBP RGS-GAIP interacting protein, C-terminus RGS-GAIP-interacting protein RGS19-interacting protein 1 regulator of G-protein signaling 19 interacting protein 1 synectin

Gipc1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Gipc1	Q9Z254	Plekhg5	Rattus norvegicus	Q6RFZ7	Confocal	16467373

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05435	GIPC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gipc1	NCBI	NCBI:10755