HOXD10 - homeobox D10 Gene

Homo sapiens

Also known as HOX4; HOX4D; HOX4E; Hox-4.4

Gene ID: 3236 | Gene type: protein coding

About HOXD10

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:176,116,778-176,119,937 (from NCBI)

This gene has 3 transcripts (splice variants), 208 orthologues, 42 paralogues and is associated with 3 phenotypes. Biased expression in endometrium (RPKM 21.4), kidney (RPKM 9.2) and 4 other tissues.

Summary

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]

HOXD10 Products(1)

mRNA	Protein	Name
NM_002148.4	NP_002139.2	homeobox protein Hox-D10

HOXD10 Protein Structure

Homeobox

0
100
200
300
340 a.a.

Protein Preferred Names

Protein Names

homeobox protein Hox-D10

homeo box 4D

Related Diseases

Diseases

Alias

Vertical Talus, Congenital

Congenital Vertical Talus	CVT
Congenital Convex Pes Valgus	Rocker-Bottom Foot Deformity
Vertical Talus	Pes Valgus, Congenital Convex
Congenital Convex Foot	Congenital Rocker-Bottom Foot
Rocker Bottom Foot	Flatfoot
Rocker-Bottom Foot	Charcot-Marie-Tooth Disease, Foot Deformity Of

Congenital Vertical Talus, Unilateral

Congenital Vertical Talus, Bilateral

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Synpolydactyly

Syndactyly Type 2	Syndactyly, Type 2
Spd

Brachydactyly-Syndactyly Syndrome

BDSD	Brachydactyly-Syndactyly-Oligodactyly Syndrome
Brachydactyly-Syndactyly, Zhao Type	BDSDO

Syndactyly, Type V

Syndactyly Type 5	SDTY5
Syndactyly With Metacarpal And Metatarsal Fusion	Syndactyly With Associated Metacarpal And Metatarsal Fusion
Postaxial Syndactyly With Metacarpal Synostosis	Sd5
Syndactyly 5	Syndactyly Type V

Clubfoot

Congenital Talipes Equinovarus	Congenital Clubfoot
Congenital Equinovarus	Equinovarus Deformity Of Foot
Club Foot

Tooth Disease

Tooth Diseases	Teeth Disease
Tooth Disorders

Preaxial Deficiency, Postaxial Polydactyly, And Hypospadias

Guttmacher Syndrome	Preaxial Deficiency, Postaxial Polydactyly And Hypospadias
Autosomal Dominant Preaxial Deficiency, Postaxial Polydactyly, And Hypospadias	Preaxial Deficiency-Postaxial Polydactyly-Hypospadias Syndrome
GUTTS

Brachydactyly

Tibia, Hypoplasia Or Aplasia Of, With Polydactyly

Hypoplastic Or Aplastic Tibia With Polydactyly	Absence Of Tibia With Polydactyly
Tibial Hemimelia-Polysyndactyly-Triphalangeal Thumb Syndrome	THYP
Tibial Hemimelia-Polydactyly-Triphalangeal Thumbs With Fibular Dimelia	Absent Tibia-Polydactyly Syndrome
Werner Mesomelic Syndrome	Hypoplastic Tibiae-Postaxial Polydactyly Syndrome
Polydactyly With Absent Tibia	Werner Mesomelic Spectrum
Hypoplasia Or Aplasia Of Tibia With Polydactyly	Wms
Tibia, Hypoplasia Of, With Polydactyly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06323	HOXD10 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HOXD10	VGNC	VGNC:67631
Mus musculus	HOXD10	MGD	MGI:96202
Canis familiaris	HOXD10	VGNC	VGNC:41762
Macaca mulatta	HOXD10	VGNC	VGNC:99368
Rattus norvegicus	HOXD10	RGD	RGD:1306511
Bos taurus	HOXD10	VGNC	VGNC:29930

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