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HOXD10 - homeobox D10 Gene

Also Known as HOX4; HOX4D; HOX4E; Hox-4.4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3236

About HOXD10

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:176,116,778-176,119,937 (from NCBI)

This gene has 3 transcripts (splice variants), 208 orthologues, 42 paralogues and is associated with 3 phenotypes. Biased expression in endometrium (RPKM 21.4), kidney (RPKM 9.2) and 4 other tissues.

Summary

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]

HOXD10 Products (1)

mRNA	Protein	Name
NM_002148.4	NP_002139.2	homeobox protein Hox-D10

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXD10 Protein Structure

Homeobox

0
100
200
300
340 a.a.

Protein Preferred Names	Protein Names
homeobox protein Hox-D10	homeo box 4D

HOXD10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HOXD10	P28358	SERPINB4	Homo sapiens	P48594	Anti Tag CoIP	33961781
Intra	HOXD10	P28358	SERPINB4	Homo sapiens	P48594	Anti Tag CoIP	28514442
Intra	HOXD10	P28358	MPND	Homo sapiens	Q8N594	Validated Y2H	32814053
Intra	HOXD10	P28358	MPND	Homo sapiens	Q8N594	Y2H Array	32814053
Intra	HOXD10	P28358	MPND	Homo sapiens	Q8N594	Y2H Pooling	32814053
Intra	HOXD10	P28358	COPS3	Homo sapiens	Q9UNS2	Validated Y2H	32814053
Intra	HOXD10	P28358	COPS3	Homo sapiens	Q9UNS2	Y2H Pooling	32814053
Intra	HOXD10	P28358	COPS3	Homo sapiens	Q9UNS2	Y2H Array	32814053
Intra	HOXD10	P28358	SKIC8	Homo sapiens	Q9GZS3	Y2H Pooling	32814053
Intra	HOXD10	P28358	SKIC8	Homo sapiens	Q9GZS3	Validated Y2H	32814053
Intra	HOXD10	P28358	SKIC8	Homo sapiens	Q9GZS3	Y2H Array	32814053
Intra	HOXD10	P28358	RASSF1	Homo sapiens	Q9NS23-4	Validated Y2H	32814053
Intra	HOXD10	P28358	RASSF1	Homo sapiens	Q9NS23-4	Y2H Pooling	32814053
Intra	HOXD10	P28358	RASSF1	Homo sapiens	Q9NS23-4	Y2H Array	32814053
Intra	HOXD10	P28358	PIAS1	Homo sapiens	O75925	Y2H Array	32814053
Intra	HOXD10	P28358	PIAS1	Homo sapiens	O75925	Validated Y2H	32814053
Intra	HOXD10	P28358	PIAS1	Homo sapiens	O75925	Y2H Pooling	32814053
Intra	HOXD10	P28358	RNF183	Homo sapiens	Q96D59	Y2H Pooling	32814053
Intra	HOXD10	P28358	RNF183	Homo sapiens	Q96D59	Validated Y2H	32814053
Intra	HOXD10	P28358	RNF183	Homo sapiens	Q96D59	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Vertical Talus, Congenital	Congenital Vertical Talus CVT Congenital Convex Pes Valgus Rocker-Bottom Foot Deformity Vertical Talus Pes Valgus, Congenital Convex Congenital Convex Foot Congenital Rocker-Bottom Foot Rocker Bottom Foot Flatfoot Rocker-Bottom Foot Charcot-Marie-Tooth Disease, Foot Deformity Of
Congenital Vertical Talus, Unilateral
Congenital Vertical Talus, Bilateral
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Synpolydactyly	Syndactyly Type 2 Syndactyly, Type 2 Spd
Brachydactyly-Syndactyly Syndrome	BDSD Brachydactyly-Syndactyly-Oligodactyly Syndrome Brachydactyly-Syndactyly, Zhao Type BDSDO
Syndactyly, Type V	Syndactyly Type 5 SDTY5 Syndactyly With Metacarpal And Metatarsal Fusion Syndactyly With Associated Metacarpal And Metatarsal Fusion Postaxial Syndactyly With Metacarpal Synostosis Sd5 Syndactyly 5 Syndactyly Type V
Clubfoot	Congenital Talipes Equinovarus Congenital Clubfoot Congenital Equinovarus Equinovarus Deformity Of Foot Club Foot
Tooth Disease	Tooth Diseases Teeth Disease Tooth Disorders
Preaxial Deficiency, Postaxial Polydactyly, And Hypospadias	Guttmacher Syndrome Preaxial Deficiency, Postaxial Polydactyly And Hypospadias Autosomal Dominant Preaxial Deficiency, Postaxial Polydactyly, And Hypospadias Preaxial Deficiency-Postaxial Polydactyly-Hypospadias Syndrome GUTTS
Brachydactyly
Tibia, Hypoplasia Or Aplasia Of, With Polydactyly	Hypoplastic Or Aplastic Tibia With Polydactyly Absence Of Tibia With Polydactyly Tibial Hemimelia-Polysyndactyly-Triphalangeal Thumb Syndrome THYP Tibial Hemimelia-Polydactyly-Triphalangeal Thumbs With Fibular Dimelia Absent Tibia-Polydactyly Syndrome Werner Mesomelic Syndrome Hypoplastic Tibiae-Postaxial Polydactyly Syndrome Polydactyly With Absent Tibia Werner Mesomelic Spectrum Hypoplasia Or Aplasia Of Tibia With Polydactyly Wms Tibia, Hypoplasia Of, With Polydactyly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06323	HOXD10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HOXD10	VGNC	VGNC:67631
Mus musculus	HOXD10	MGD	MGI:96202
Canis familiaris	HOXD10	VGNC	VGNC:41762
Macaca mulatta	HOXD10	VGNC	VGNC:99368
Rattus norvegicus	HOXD10	RGD	RGD:1306511
Bos taurus	HOXD10	VGNC	VGNC:29930
Others	HOXD10	NCBI