Nckap1 - NCK-associated protein 1 Gene

Also Known as H19; Hem2; Nap1; mh19; Hem-2; p125Nap1; mKIAA0587

Species: Mus musculus

Gene Type: protein coding
Gene ID: 50884

Summary

Predicted to contribute to small GTPase binding activity. Involved in positive regulation of actin filament polymerization and positive regulation of lamellipodium assembly. Acts upstream of or within several processes, including apical protein localization; embryonic morphogenesis; and segmentation. Located in lamellipodium and ruffle. Part of filamentous actin. Is active in postsynapse. Is expressed in several structures, including alimentary system; genitourinary system; immune system; nervous system; and sensory organ. Orthologous to human NCKAP1 (NCK associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Nckap1 Products (4)

mRNA Protein Name
NM_001290745.1 NP_001277674.1 nck-associated protein 1 isoform a
NM_001355410.1 NP_001342339.1 nck-associated protein 1 isoform c
NM_001355411.1 NP_001342340.1 nck-associated protein 1 isoform d
NM_016965.3 NP_058661.1 nck-associated protein 1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21946561 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within apical protein localization IDA
IDA: Inferred from direct assay
16831833 MGI
acts upstream of or within basal protein localization IDA
IDA: Inferred from direct assay
16831833 MGI
acts upstream of or within cell migration involved in gastrulation IMP
IMP: Inferred from mutant phenotype
16831833 MGI
acts upstream of or within embryonic body morphogenesis IMP
IMP: Inferred from mutant phenotype
16831833 MGI
acts upstream of or within embryonic foregut morphogenesis IMP
IMP: Inferred from mutant phenotype
16831833 MGI
acts upstream of or within embryonic heart tube development IMP
IMP: Inferred from mutant phenotype
16831833 MGI
acts upstream of or within endoderm development IMP
IMP: Inferred from mutant phenotype
16831833 MGI
acts upstream of or within establishment or maintenance of actin cytoskeleton polarity IMP
IMP: Inferred from mutant phenotype
16831833 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
16831833 MGI
acts upstream of or within lamellipodium assembly IDA
IDA: Inferred from direct assay
14765121 MGI
acts upstream of or within lamellipodium assembly IMP
IMP: Inferred from mutant phenotype
16831833 MGI
acts upstream of or within mesodermal cell migration IMP
IMP: Inferred from mutant phenotype
16831833 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
16831833 MGI
acts upstream of or within notochord development IMP
IMP: Inferred from mutant phenotype
16831833 MGI
acts upstream of or within notochord morphogenesis IMP
IMP: Inferred from mutant phenotype
16831833 MGI
acts upstream of or within paraxial mesoderm development IMP
IMP: Inferred from mutant phenotype
16831833 MGI
acts upstream of or within paraxial mesoderm morphogenesis IMP
IMP: Inferred from mutant phenotype
16831833 MGI
involved in positive regulation of actin filament polymerization IDA
IDA: Inferred from direct assay
27927633 MGI
involved in positive regulation of lamellipodium assembly IDA
IDA: Inferred from direct assay
27927633 MGI
acts upstream of or within protein stabilization IMP
IMP: Inferred from mutant phenotype
16831833 MGI
acts upstream of or within regulation of protein localization IMP
IMP: Inferred from mutant phenotype
16831833 MGI
acts upstream of or within somitogenesis IMP
IMP: Inferred from mutant phenotype
16831833 MGI
acts upstream of or within zygotic determination of anterior/posterior axis, embryo IMP
IMP: Inferred from mutant phenotype
16831833 MGI
Cellular Component GO Annotation Evidence References Source
part of filamentous actin IDA
IDA: Inferred from direct assay
27927633 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
14765121 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
24050404 MGI
is active in postsynapse IEP
IEP: Inferred from expression pattern
24050404 MGI
located in ruffle IDA
IDA: Inferred from direct assay
27927633 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nck-associated protein 1

  • brain protein H19

  • membrane-associated protein HEM-2

Nckap1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Nckap1 P28660 Myo16 Mus musculus Q5DU14
Anti Bait CoIP
21946561
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09082 NCKAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09083 NCKAP1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nckap1 NCBI NCBI:10787