Nckap1 - NCK-associated protein 1 Gene

Mus musculus

Also known as H19; Hem2; Nap1; mh19; Hem-2; p125Nap1; mKIAA0587

Gene ID: 50884 | Gene type: protein coding

About Nckap1

Summary

Predicted to contribute to small GTPase binding activity. Involved in positive regulation of actin filament polymerization and positive regulation of lamellipodium assembly. Acts upstream of or within several processes, including apical protein localization; embryonic morphogenesis; and segmentation. Located in lamellipodium and ruffle. Part of filamentous actin. Is active in postsynapse. Is expressed in several structures, including alimentary system; genitourinary system; immune system; nervous system; and sensory organ. Orthologous to human NCKAP1 (NCK associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Nckap1 Products(4)

mRNA	Protein	Name
NM_001290745.1	NP_001277674.1	nck-associated protein 1 isoform a
NM_001355410.1	NP_001342339.1	nck-associated protein 1 isoform c
NM_001355411.1	NP_001342340.1	nck-associated protein 1 isoform d
NM_016965.3	NP_058661.1	nck-associated protein 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21946561	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within apical protein localization	IDA IDA: Inferred from direct assay	16831833	MGI
acts upstream of or within basal protein localization	IDA IDA: Inferred from direct assay	16831833	MGI
acts upstream of or within cell migration involved in gastrulation	IMP IMP: Inferred from mutant phenotype	16831833	MGI
acts upstream of or within embryonic body morphogenesis	IMP IMP: Inferred from mutant phenotype	16831833	MGI
acts upstream of or within embryonic foregut morphogenesis	IMP IMP: Inferred from mutant phenotype	16831833	MGI
acts upstream of or within embryonic heart tube development	IMP IMP: Inferred from mutant phenotype	16831833	MGI
acts upstream of or within endoderm development	IMP IMP: Inferred from mutant phenotype	16831833	MGI
acts upstream of or within establishment or maintenance of actin cytoskeleton polarity	IMP IMP: Inferred from mutant phenotype	16831833	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	16831833	MGI
acts upstream of or within lamellipodium assembly	IDA IDA: Inferred from direct assay	14765121	MGI
acts upstream of or within lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	16831833	MGI
acts upstream of or within mesodermal cell migration	IMP IMP: Inferred from mutant phenotype	16831833	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	16831833	MGI
acts upstream of or within notochord development	IMP IMP: Inferred from mutant phenotype	16831833	MGI
acts upstream of or within notochord morphogenesis	IMP IMP: Inferred from mutant phenotype	16831833	MGI
acts upstream of or within paraxial mesoderm development	IMP IMP: Inferred from mutant phenotype	16831833	MGI
acts upstream of or within paraxial mesoderm morphogenesis	IMP IMP: Inferred from mutant phenotype	16831833	MGI
involved in positive regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	27927633	MGI
involved in positive regulation of lamellipodium assembly	IDA IDA: Inferred from direct assay	27927633	MGI
acts upstream of or within protein stabilization	IMP IMP: Inferred from mutant phenotype	16831833	MGI
acts upstream of or within regulation of protein localization	IMP IMP: Inferred from mutant phenotype	16831833	MGI
acts upstream of or within somitogenesis	IMP IMP: Inferred from mutant phenotype	16831833	MGI
acts upstream of or within zygotic determination of anterior/posterior axis, embryo	IMP IMP: Inferred from mutant phenotype	16831833	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of filamentous actin	IDA IDA: Inferred from direct assay	27927633	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	14765121	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	24050404	MGI
is active in postsynapse	IEP IEP: Inferred from expression pattern	24050404	MGI
located in ruffle	IDA IDA: Inferred from direct assay	27927633	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nck-associated protein 1

brain protein H19

membrane-associated protein HEM-2

Nckap1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nckap1	P28660	Myo16	Mus musculus	Q5DU14	Anti Bait CoIP	21946561

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09082	NCKAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09083	NCKAP1L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nckap1	NCBI	NCBI:10787

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