2. Gene
  3. Porcn - porcupine O-acyltransferase Gene

Porcn - porcupine O-acyltransferase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ppn; Mg61; porc; Mporc; mMg61; DXHXS7465e; 2410004O13Rik

Gene ID: 53627 | Gene type: protein coding

About Porcn

Chromosome X: 8,060,087-8,072,764 reverse strand.GRCm39:CM001013.3

This gene has 7 transcripts (splice variants), 268 orthologues, 5 paralogues and is associated with 33 phenotypes. Broad expression in cerebellum adult (RPKM 42.), ovary adult (RPKM 21.2) and 21 other tissues.

Summary

Enables Wnt-protein binding activity and palmitoleoyltransferase activity. Involved in Wnt signaling pathway; protein palmitoleylation; and regulation of postsynaptic membrane neurotransmitter receptor levels. Acts upstream of or within canonical Wnt signaling pathway and glycoprotein metabolic process. Located in endoplasmic reticulum and glutamatergic synapse. Is integral component of endoplasmic reticulum membrane. Part of AMPA glutamate receptor complex. Is expressed in several structures, including anterior visceral endoderm; eye; genitourinary system; nervous system; and primitive streak. Used to study focal dermal hypoplasia. Human ortholog(s) of this gene implicated in focal dermal hypoplasia. Orthologous to human PORCN (Porcupine O-acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Porcn Products(5)

mRNA Protein Name
NM_016913.4 NP_058609.1 protein-serine O-palmitoleoyltransferase porcupine isoform A
NM_145907.4 NP_665914.1 protein-serine O-palmitoleoyltransferase porcupine isoform C
NM_001308474.1 NP_001295403.1 protein-serine O-palmitoleoyltransferase porcupine isoform E
NM_145908.4 NP_665915.1 protein-serine O-palmitoleoyltransferase porcupine isoform B
NM_023638.4 NP_076127.1 protein-serine O-palmitoleoyltransferase porcupine isoform D

Porcn Protein Structure

MBOAT

MBOAT: cl00738 (30 - 342)

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  • 461 a.a.
Protein Preferred Names Protein Names

protein-serine O-palmitoleoyltransferase porcupine

porcupine homolog

probable protein-cysteine N-palmitoyltransferase porcupine

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-17545 LGK974 Inhibitor 99.92% Phase 2
HY-18988 ETC-159 Inhibitor 98.96% Phase 1
Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13912 IWP-2 Inhibitor 99.51% Unkown
HY-15659 Wnt-C59 Inhibitor 99.86% Unkown
HY-15825 IWP L6 Inhibitor 99.50% Unkown
HY-100853 IWP-O1 Inhibitor 99.61% Unkown
HY-100536 IWP-3 98.23% Unkown
HY-111472 Porcn-IN-1 Inhibitor 99.92% Unkown
HY-107570 IWP-12 Inhibitor ≥99.0% Unkown
HY-13912G IWP-2 (GMP) Inhibitor / Unkown
HY-15659G Wnt-C59 (GMP) Inhibitor / Unkown
HY-156551 Porcn-IN-2 Inhibitor / Unkown
HY-RS10881 PORCN Human Pre-designed siRNA Set A / Unkown
HY-RS10882 Porcn Mouse Pre-designed siRNA Set A / Unkown
HY-RS10883 Porcn Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Porcn NCBI NCBI:64840