SMYD2 - SET and MYND domain containing 2 Gene

Homo sapiens

Also known as KMT3C; HSKM-B; ZMYND14

Gene ID: 56950 | Gene type: protein coding

About SMYD2

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:214,281,159-214,337,131 (from NCBI)

This gene has 6 transcripts (splice variants), 229 orthologues and 5 paralogues. Broad expression in heart (RPKM 86.3), testis (RPKM 19.8) and 22 other tissues.

Summary

SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied by OMIM, Nov 2008]

SMYD2 Products(3)

mRNA	Protein	Name
XM_047425700.1	XP_047281656.1	N-lysine methyltransferase SMYD2 isoform X1
NM_020197.3	NP_064582.2	N-lysine methyltransferase SMYD2
XM_047425702.1	XP_047281658.1	N-lysine methyltransferase SMYD2 isoform X2

SMYD2 Protein Structure

SET

zf-MYND

0
100
200
300
400
433 a.a.

Protein Preferred Names

Protein Names

N-lysine methyltransferase SMYD2

SET and MYND domain-containing protein 2	histone methyltransferase SMYD2
lysine N-methyltransferase 3C	zinc finger, MYND domain containing 14

Recombinant SMYD2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76079	SMYD2 Protein, Human (sf9, His)	Q9NRG4 (M1-H433)	≥95%

Related Diseases

Diseases

Alias

Wolf-Hirschhorn Syndrome

Pitt-Rogers-Danks Syndrome	WHS
Chromosome 4p16.3 Deletion Syndrome	Wittwer Syndrome
4p- Syndrome	Pitt Syndrome
4p Deletion Syndrome	Distal Deletion 4p
Distal Monosomy 4p	Telomeric Deletion 4p
Prds	4p Syndrome
Chromosome 4p Syndrome	Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation
Wolf Syndrome	Chromosome 4p Deletion Syndrome
Chromosome 4p Monosomy	Del Syndrome
Monosomy 4p	Partial Monosomy 4p
Chromosome 4 Short Arm Deletion

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type	Adpkd
Polycystic Kidney Diseases	Polycystic Kidney, Autosomal Dominant
Congenital Biliary Ectasias	Polycystic Kidney And Hepatic Disease 1
Polycystic Kidney Disease, Autosomal Dominant	Kidney, Polycystic, Disease, Autosomal Dominant
Adult Polycystic Kidney Disease	Polycystic Kidney, Adult Type
Apckd - [Autosomal Polycystic Kidney Disease]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15226	AZ505	Inhibitor	99.99%	Unkown
HY-19313	LLY-507	Inhibitor	98.28%	Unkown
HY-19546	BAY-598	Inhibitor	99.30%	Unkown
HY-134828	AZ506	Inhibitor	99.74%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SMYD2	VGNC	VGNC:53836
Macaca mulatta	SMYD2	VGNC	VGNC:77750
Felis catus	SMYD2	VGNC	VGNC:97638
Rattus norvegicus	SMYD2	RGD	RGD:727785
Bos taurus	SMYD2	VGNC	VGNC:35043
Mus musculus	SMYD2	MGD	MGI:1915889
Others	SMYD2	NCBI

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