SMYD2 - SET and MYND domain containing 2 Gene

Also Known as KMT3C; HSKM-B; ZMYND14

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56950

About SMYD2

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:214,281,159-214,337,131 (from NCBI)

This gene has 6 transcripts (splice variants), 229 orthologues and 5 paralogues. Broad expression in heart (RPKM 86.3), testis (RPKM 19.8) and 22 other tissues.

Summary

SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied by OMIM, Nov 2008]

SMYD2 Products (3)

mRNA	Protein	Name
XM_047425700.1	XP_047281656.1	N-lysine methyltransferase SMYD2 isoform X1
NM_020197.3	NP_064582.2	N-lysine methyltransferase SMYD2
XM_047425702.1	XP_047281658.1	N-lysine methyltransferase SMYD2 isoform X2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables p53 binding	IPI IPI: Inferred from physical interaction	17108971	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17805299	GOA
enables protein-lysine N-methyltransferase activity	IDA IDA: Inferred from direct assay	17108971	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17108971	GOA
involved in peptidyl-lysine monomethylation	IDA IDA: Inferred from direct assay	17108971	GOA
involved in regulation of DNA damage response, signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	17108971	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	24880080	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMYD2 Protein Structure

SET

zf-MYND

0
100
200
300
400
433 a.a.

Protein Preferred Names	Protein Names
N-lysine methyltransferase SMYD2	SET and MYND domain-containing protein 2 histone methyltransferase SMYD2 lysine N-methyltransferase 3C zinc finger, MYND domain containing 14

SMYD2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SMYD2	Q9NRG4	SNX11	Homo sapiens	Q9Y5W9	Validated Y2H	32296183
Intra	SMYD2	Q9NRG4	TP53	Homo sapiens	P04637	ITC	21782458
Intra	SMYD2	Q9NRG4	TP53	Homo sapiens	P04637	X-Ray Diffraction	21782458
Intra	SMYD2	Q9NRG4	TP53	Homo sapiens	P04637	Radiolabeled Methyl	21782458
Intra	SMYD2	Q9NRG4	TP53	Homo sapiens	P04637	Methyltransferase Ass	21782458

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SMYD2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76079	SMYD2 Protein, Human (sf9, His)	Q9NRG4-1 (M1-H433)	≥ 95%, as determined by reducing SDS-PAGE.

SMYD2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85491	SMYD2 Antibody	WB, IHC-P, IF-Tissue	Human, Mouse

Related Diseases

Diseases	Alias
Wolf-Hirschhorn Syndrome	Pitt-Rogers-Danks Syndrome WHS Chromosome 4p16.3 Deletion Syndrome Wittwer Syndrome 4p- Syndrome Pitt Syndrome 4p Deletion Syndrome Distal Deletion 4p Distal Monosomy 4p Telomeric Deletion 4p Prds 4p Syndrome Chromosome 4p Syndrome Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation Wolf Syndrome Chromosome 4p Deletion Syndrome Chromosome 4p Monosomy Del Syndrome Monosomy 4p Partial Monosomy 4p Chromosome 4 Short Arm Deletion
Autosomal Dominant Polycystic Kidney Disease	Polycystic Kidney Disease, Adult Type Adpkd Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Congenital Biliary Ectasias Polycystic Kidney And Hepatic Disease 1 Polycystic Kidney Disease, Autosomal Dominant Kidney, Polycystic, Disease, Autosomal Dominant Adult Polycystic Kidney Disease Polycystic Kidney, Adult Type Apckd - [Autosomal Polycystic Kidney Disease]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19313	LLY-507	Inhibitor	99.09%	Unkown
HY-15226	AZ505	Inhibitor	99.99%	Unkown
HY-141877	MS4322	Degrader	99.14%	Unkown
HY-19546	BAY-598	Inhibitor	99.33%	Unkown
HY-15226A	AZ505 ditrifluoroacetate	Inhibitor	99.89%	Unkown
HY-134828	AZ506	Inhibitor	99.74%	Unkown
HY-141877B	MS4322 (isomer)		99.87%	Unkown
HY-19563	A-893	Inhibitor	/	Unkown
HY-111367	MS2734	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SMYD2	VGNC	VGNC:53836
Macaca mulatta	SMYD2	VGNC	VGNC:77750
Felis catus	SMYD2	VGNC	VGNC:97638
Rattus norvegicus	SMYD2	RGD	RGD:727785
Bos taurus	SMYD2	VGNC	VGNC:35043
Mus musculus	SMYD2	MGD	MGI:1915889
Others	SMYD2	NCBI