1. Epigenetics
  2. Histone Methyltransferase

LLY-507 

Cat. No.: HY-19313 Purity: 99.09%
Data Sheet SDS Handling Instructions

LLY-507 is a potent inhibitor of SMYD2 with IC50 < 15 nM, is >100-fold selective for SMYD2 over a broad range of methyltransferase and non-methyltransferase targets.

For research use only. We do not sell to patients.
LLY-507 Chemical Structure

LLY-507 Chemical Structure

CAS No. : 1793053-37-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $126 In-stock
5 mg $100 In-stock
10 mg $180 In-stock
25 mg $390 In-stock
50 mg $700 In-stock
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

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  • References

Description

LLY-507 is a potent inhibitor of SMYD2 with IC50 < 15 nM, is >100-fold selective for SMYD2 over a broad range of methyltransferase and non-methyltransferase targets. IC50 value: < 15 nM Target: SMYD2 in vitro: LLY-507 shows the inhibitor binding in the substrate peptide binding pocket. LLY-507 is active in cells as measured by reduction of SMYD2-induced monomethylation of p53 Lys370 at submicromolar concentrations. LLY-507 inhibits the proliferation of several esophageal, liver, and breast cancer cell lines in a dose-dependent manner. LLY-507 serves as a valuable chemical probe to aid in the dissection of SMYD2 function in cancer and other biological processes.

References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.7399 mL 8.6993 mL 17.3986 mL
5 mM 0.3480 mL 1.7399 mL 3.4797 mL
10 mM 0.1740 mL 0.8699 mL 1.7399 mL
References
Molecular Weight

574.76

Formula

C₃₆H₄₂N₆O

CAS No.

1793053-37-8

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 15 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
LLY-507
Cat. No.:
HY-19313
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