1. Epigenetics
  2. Histone Methyltransferase

LLY-507 

Cat. No.: HY-19313 Purity: 99.09%
Handling Instructions

LLY-507 is a potent inhibitor of SMYD2 with IC50 < 15 nM, is >100-fold selective for SMYD2 over a broad range of methyltransferase and non-methyltransferase targets.

For research use only. We do not sell to patients.

LLY-507 Chemical Structure

LLY-507 Chemical Structure

CAS No. : 1793053-37-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 126 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 390 In-stock
Estimated Time of Arrival: December 31
50 mg USD 700 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

    LLY-507 purchased from MCE. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129.

    The effects of treatment with the indicated epigenetic inhibitors on cleaved PARP (Clv-PARP) expression in both PC9/ER and HCC827/ER cells. β-actin is used as a loading control.

    LLY-507 purchased from MCE. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129.

    H3K9Me2, PTEN, p-AKT, and AKT expression levels are measured in PC9/ER xenograft tumor tissues. β-actin is used as a loading control.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    LLY-507 is a potent inhibitor of SMYD2 with IC50 < 15 nM, is >100-fold selective for SMYD2 over a broad range of methyltransferase and non-methyltransferase targets. IC50 value: < 15 nM Target: SMYD2 in vitro: LLY-507 shows the inhibitor binding in the substrate peptide binding pocket. LLY-507 is active in cells as measured by reduction of SMYD2-induced monomethylation of p53 Lys370 at submicromolar concentrations. LLY-507 inhibits the proliferation of several esophageal, liver, and breast cancer cell lines in a dose-dependent manner. LLY-507 serves as a valuable chemical probe to aid in the dissection of SMYD2 function in cancer and other biological processes.

    Solvent & Solubility
    In Vitro: 

    DMSO : 15 mg/mL (26.10 mM; Need ultrasonic and warming)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7399 mL 8.6993 mL 17.3986 mL
    5 mM 0.3480 mL 1.7399 mL 3.4797 mL
    10 mM 0.1740 mL 0.8699 mL 1.7399 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    574.76

    Formula

    C₃₆H₄₂N₆O

    CAS No.

    1793053-37-8

    SMILES

    O=C(C1=CC(C2=CC=CC=C2N3CCN(CCN4C=C(C)C5=C4C=CC=C5)CC3)=CC(C#N)=C1)NCCCN6CCCC6

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

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    Product Name:
    LLY-507
    Cat. No.:
    HY-19313
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    LLY-507

    Cat. No.: HY-19313