Pggt1b - protein geranylgeranyltransferase type I subunit beta Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81746

Summary

Enables heterocyclic compound binding activity. Contributes to several functions, including CAAX-protein geranylgeranyltransferase activity; peptide binding activity; and zinc ion binding activity. Involved in several processes, including negative regulation of nitric-oxide synthase biosynthetic process; positive regulation of cell population proliferation; and protein geranylgeranylation. Part of CAAX-protein geranylgeranyltransferase complex. Orthologous to human PGGT1B (protein geranylgeranyltransferase type I subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Pggt1b Products (1)

mRNA Protein Name
NM_031082.2 NP_112344.1 geranylgeranyl transferase type-1 subunit beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to CAAX-protein geranylgeranyltransferase activity IDA
IDA: Inferred from direct assay
8089111 RGD
enables CAAX-protein geranylgeranyltransferase activity IDA
IDA: Inferred from direct assay
14609943 RGD
enables heterocyclic compound binding IDA
IDA: Inferred from direct assay
15248757 RGD
contributes to peptide binding IDA
IDA: Inferred from direct assay
9705207 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
14609943 RGD
contributes to small molecule binding IDA
IDA: Inferred from direct assay
15248757 RGD
contributes to zinc ion binding IDA
IDA: Inferred from direct assay
15248757 RGD
enables zinc ion binding IDA
IDA: Inferred from direct assay
14609943 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of nitric-oxide synthase biosynthetic process IMP
IMP: Inferred from mutant phenotype
9153192 RGD
involved in positive regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
10544242 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
10544242 RGD
involved in protein geranylgeranylation IDA
IDA: Inferred from direct assay
14609943 RGD
involved in response to cytokine IMP
IMP: Inferred from mutant phenotype
9153192 RGD
Cellular Component GO Annotation Evidence References Source
part of CAAX-protein geranylgeranyltransferase complex IDA
IDA: Inferred from direct assay
14609943 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

geranylgeranyl transferase type-1 subunit beta

  • GGTase-I-beta

  • geranylgeranyl transferase type I subunit beta

  • geranylgeranyltransferase type 1 beta

  • geranylgeranyltransferase type I (GGTase-I)

  • protein geranylgeranyltransferase type 1 subunit beta

  • protein geranylgeranyltransferase type I, beta subuni

Pggt1b Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Pggt1b P53610 Fnta Rattus norvegicus Q04631
Pull Down
18957540
Intra
Pggt1b P53610 Fnta Rattus norvegicus Q04631
X-Ray Diffraction
15248757
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10383 PGGT1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21169 Pggt1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27686 Pggt1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pggt1b NCBI NCBI:5229