PGGT1B - protein geranylgeranyltransferase type I subunit beta Gene

Homo sapiens

Also known as BGGI; GGTI

Gene ID: 5229 | Gene type: protein coding

About PGGT1B

Cytogenetic location: 5q22.3 Genomic coordinates (GRCh38): 5:115,204,012-115,262,877 (from NCBI)

This gene has 5 transcripts (splice variants), 201 orthologues and 2 paralogues. Ubiquitous expression in colon (RPKM 3.0), spleen (RPKM 2.3) and 25 other tissues.

Summary

Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The Enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related Enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]

PGGT1B Products(1)

mRNA	Protein	Name
NM_005023.4	NP_005014.2	geranylgeranyl transferase type-1 subunit beta

PGGT1B Protein Structure

SQHop_cyclase_N

Prenyltrans

0
100
200
300
377 a.a.

Protein Preferred Names

Protein Names

geranylgeranyl transferase type-1 subunit beta

CTC-428G20.3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10383	PGGT1B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PGGT1B	VGNC	VGNC:32788
Canis familiaris	PGGT1B	VGNC	VGNC:44459
Mus musculus	PGGT1B	MGD	MGI:1917514
Felis catus	PGGT1B	VGNC	VGNC:68814
Macaca mulatta	PGGT1B	VGNC	VGNC:75965
Rattus norvegicus	PGGT1B	RGD	RGD:621754

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