Kcnq1 - potassium voltage-gated channel subfamily Q member 1 Gene

Also Known as Kvlqt1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84020

Summary

Enables delayed rectifier Potassium Channel activity; identical protein binding activity; and outward rectifier Potassium Channel activity. Involved in several processes, including male gonad development; regulation of secretion; and response to anesthetic. Located in basolateral plasma membrane; sarcolemma; and zymogen granule membrane. Is integral component of plasma membrane. Part of voltage-gated Potassium Channel complex. Used to study hypertension and long QT syndrome. Human ortholog(s) of this gene implicated in heart conduction disease (multiple) and long QT syndrome (multiple). Orthologous to human KCNQ1 (potassium voltage-gated channel subfamily Q member 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcnq1 Products (1)

mRNA Protein Name
NM_032073.2 NP_114462.2 potassium voltage-gated channel subfamily KQT member 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables delayed rectifier potassium channel activity IDA
IDA: Inferred from direct assay
11220365 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
20962273 RGD
enables outward rectifier potassium channel activity IDA
IDA: Inferred from direct assay
11220365 RGD
enables potassium channel activity IDA
IDA: Inferred from direct assay
11804849 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15389592 RGD
Biological Process GO Annotation Evidence References Source
involved in intestinal absorption IMP
IMP: Inferred from mutant phenotype
16314573 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
15389592 RGD
involved in negative regulation of insulin secretion IDA
IDA: Inferred from direct assay
16133261 RGD
involved in potassium ion transport IDA
IDA: Inferred from direct assay
16133261 RGD
involved in regulation of membrane potential IDA
IDA: Inferred from direct assay
11804849 RGD
involved in response to anesthetic IDA
IDA: Inferred from direct assay
12616988 RGD
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
15843438 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
14670813 RGD
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
15389592 RGD
located in zymogen granule membrane IDA
IDA: Inferred from direct assay
18216164 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily KQT member 1

  • IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1

  • KQT-like 1

  • potassium channel, voltage-gated KQT-like subfamily Q, member 1

  • potassium voltage-gated channel, KQT-like subfamily, member 1

  • voltage-gated potassium channel subunit Kv

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108577 XE991 dihydrochloride Inhibitor / Unkown
HY-12343 ML277 Activator 98.46% Unkown
HY-108577A XE991 Inhibitor 99.69% Unkown
HY-108591 L-364,373 Activator 99.65% Unkown
HY-18063 ML252 Inhibitor 99.9% Unkown
HY-108587 ICA 110381 Modulator 99.80% Unkown
HY-108592 UCL 2077 Inhibitor 98.91% Unkown
HY-145992 KCNQ1 activator-1 Activator 99.03% Unkown
HY-18063A ML252 hydrochloride Inhibitor 98.5% Unkown
HY-117174 L-735821 Inhibitor / Unkown
HY-121520 Docosahexaenoyl glycine Activator / Unkown
HY-122504 Linoleoyl glycine Inhibitor / Unkown
HY-179065 VU0494372 Activator / Unkown
HY-183323 MmpL3-IN-6 / Unkown
HY-184207 Zinc13732787 Inhibitor / Unkown
HY-RS07173 KCNQ1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-121977 IKs124 Inhibitor / Unkown
HY-RS18286 Kcnq1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24764 Kcnq1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnq1 NCBI NCBI:3784