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Cat. No.: HY-117174

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L-735821

L-735821 is a Potassium channel blocker and an antagonist of I_Ks. L-735821 inhibits the KCNQ1 channel activity with an EC₅₀ of 0.08 μM. L-735821 can increase I_Ks and I_Kr current-voltage relations in rabbit ventricular myocytes. L-735821 fully abolishes I_Ks in isolated human ventricular myocytes at 100 nmol/L. L-735821 can easily enter single myocytes.

For research use only. We do not sell to patients.

CAS No.: 170228-29-2
Formula: C₂₅H₁₉Cl₂N₃O₂
Molecular Weight:464.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

L-735821 Chemical Structure

CAS No.: 170228-29-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

CAS No. 170228-29-2
Molecular Weight 464.34
Formula C₂₅H₁₉Cl₂N₃O₂
SMILES

O=C(/C=C/C1=CC=C(C=C1Cl)Cl)N[C@H]2C(N(C3=CC=CC=C3C(C4=CC=CC=C4)=N2)C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lengyel, C., et al., (2001). Pharmacological block of the slow component of the outward delayed rectifier current (I(Ks)) fails to lengthen rabbit ventricular muscle QT(c) and action potential duration. British journal of pharmacology, 132(1), 101-110. [Content Brief]

[2]. ost, N., et al., (2005). Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle. Circulation, 112(10), 1392-1399. [Content Brief]

[3]. Manikkam, M., et al., (2002). Potassium channel antagonists influence porcine granulosa cell proliferation, differentiation, and apoptosis. Biology of reproduction, 67(1), 88-98. [Content Brief]

[4]. Tinel, N., et al., (1998). The KCNQ2 potassium channel: splice variants, functional and developmental expression. Brain localization and comparison with KCNQ3. FEBS letters, 438(3), 171-176. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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