170228-29-2
Chemical Structure
L-735821
- CAS. Nr.: 170228-29-2
- Formula:C25H19Cl2N3O2
- Molecular Weight:464.34
IUPAC Name: (R,E)-3-(2,4-dichlorophenyl)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)acrylamide
InChIKey: BYULDQRRUINTAA-SWDTZWKESA-N
SMILES: O=C(/C=C/C1=CC=C(C=C1Cl)Cl)N[C@H]2C(N(C3=CC=CC=C3C(C4=CC=CC=C4)=N2)C)=O
Biological Activity: L-735821 is a Potassium channel blocker and an antagonist of IKs. L-735821 inhibits the KCNQ1 channel activity with an EC50 of 0.08 μM. L-735821 can increase IKs and IKr current-voltage relations in rabbit ventricular myocytes. L-735821 fully abolishes IKs in isolated human ventricular myocytes at 100 nmol/L. L-735821 can easily enter single myocytes[1][2][3][4].
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L-735821 | L-735821 is a Potassium channel blocker and an antagonist of IKs. L-735821 inhibits the KCNQ1 channel activity with an EC50 of 0.08 μM. L-735821 can increase IKs and IKr current-voltage relations in rabbit ventricular myocytes. L-735821 fully abolishes IKs in isolated human ventricular myocytes at 100 nmol/L. L-735821 can easily enter single myocytes. | |||||||||||||||||||||
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- [1]. Lengyel, C., et al., (2001). Pharmacological block of the slow component of the outward delayed rectifier current (I(Ks)) fails to lengthen rabbit ventricular muscle QT(c) and action potential duration. British journal of pharmacology, 132(1), 101-110. [Content Brief]
- [2]. ost, N., et al., (2005). Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle. Circulation, 112(10), 1392-1399. [Content Brief]
- [3]. Manikkam, M., et al., (2002). Potassium channel antagonists influence porcine granulosa cell proliferation, differentiation, and apoptosis. Biology of reproduction, 67(1), 88-98. [Content Brief]
- [4]. Tinel, N., et al., (1998). The KCNQ2 potassium channel: splice variants, functional and developmental expression. Brain localization and comparison with KCNQ3. FEBS letters, 438(3), 171-176. [Content Brief]
Keywords
