1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. ICA 110381

ICA 110381 

Cat. No.: HY-108587
Handling Instructions

ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM).

For research use only. We do not sell to patients.

ICA 110381 Chemical Structure

ICA 110381 Chemical Structure

CAS No. : 325457-99-6

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Description

ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM)[1].

IC50 & Target

EC50: 0.38 μM (KCNQ2/Q3 potassium channel)[1]
IC50: 15 μM (KCNQ1)[1]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

267.11

Formula

C₁₂H₈Cl₂N₂O

CAS No.

325457-99-6

SMILES

O=C(NC1=CC=C(Cl)N=C1)C2=CC=C(Cl)C=C2

Shipping

Room temperature in continental US; may vary elsewhere

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ICA 110381
Cat. No.:
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ICA 110381

Cat. No.: HY-108587