2. Anti-infection
  3. Bacterial
  4. MmpL3-IN-6

MmpL3-IN-6 is a mycobacterial membrane protein large 3 (MmpL3) transporter inhibitor and is an antitubercular agent. MmpL3-IN-6 exerts bactericidal activity against replicating Mycobacterium tuberculosis.MmpL3-IN-6 retains activity against drug-resistant Mycobacterium tuberculosis.MmpL3-IN-6 can be used for the research of tuberculosis.

For research use only. We do not sell to patients.

MmpL3-IN-6

MmpL3-IN-6 Chemical Structure

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MmpL3-IN-6 Related Antibodies

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Description

MmpL3-IN-6 is a mycobacterial membrane protein large 3 (MmpL3) transporter inhibitor and is an antitubercular agent. MmpL3-IN-6 exerts bactericidal activity against replicating Mycobacterium tuberculosis.MmpL3-IN-6 retains activity against drug-resistant Mycobacterium tuberculosis.MmpL3-IN-6 can be used for the research of tuberculosis[1].

In Vitro

MmpL3-IN-6 (Compound 12) (7 days) inhibits Mycobacterium tuberculosis H37Rv growth with an MIC of 1.00 μM, shows moderate cytotoxicity against HepG2 cells with an IC50 of 38 μM, has an aqueous solubility of 105 μM at pH 7.4, and a logD of 2.4[1].
MmpL3-IN-6 exhibits bactericidal activity against replicating Mycobacterium tuberculosis H37Rv with an MBC99 of 1.90 μM[1].
MmpL3-IN-6 has enhanced effectiveness when Mycobacterium tuberculosis MmpL3 is silenced via CRISPRi, confirming MmpL3 as the primary target[1].
MmpL3-IN-6 (10 μM) inhibits hERG K+ channel activity by 90% and does not significantly inhibit KCNQ1 K+ channels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MmpL3-IN-6 Related Antibodies
Parmacokinetics
Species Dose Route F CLblood CLunbound
Mice[1] 3 mg/kg i.v. / 77 mL/min/kg 549 mL/min/kg
Mice[1] 10 mg/kg p.o. 8 % / /
Molecular Weight

407.62

Formula

C24H33N3OSi
SMILES

C[Si]1(CCN(CC1)CC2=NN(C(C3CC3)=C2)C4=CC=C(C=C4)C5=CCOCC5)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MmpL3-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MmpL3-IN-6BacterialMmpL3 mutant strainsMtbMmpL3 transporterdrug-resistant Mycobacterium tuberculosisMycobacterium tuberculosis H37RvMycobacterium tuberculosistuberculosiscell wall biosynthesisHepG2 cellshERG K+ channelKCNQ1 K+ channelsInhibitorinhibitorinhibit

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