CPNE6 - copine 6 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9362

About CPNE6

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:24,070,949-24,078,087 (from NCBI)

This gene has 20 transcripts (splice variants), 1 gene allele, 193 orthologues and 8 paralogues. Biased expression in brain (RPKM 23.5), small intestine (RPKM 2.5) and 3 other tissues.

Summary

This gene encodes a member of the copine family. Members of this family are calcium-dependent, phospholipid-binding proteins with C2 domains, two calcium- and phospholipid-binding domains. Through their domain structure and lipid binding capabilities, these proteins may play a role in membrane trafficking. This protein is thought to be brain-specific and has a domain structure of two N-terminal C2 domains and one von Willebrand factor A domain. It may have a role in synaptic plasticity. [provided by RefSeq, Jul 2013]

CPNE6 Products (5)

mRNA	Protein	Name
NM_001280558.2	NP_001267487.1	copine-6 isoform 1
NM_001385056.1	NP_001371985.1	copine-6 isoform 2
NM_001385057.1	NP_001371986.1	copine-6 isoform 2
NM_001385058.1	NP_001371987.1	copine-6 isoform 2
NM_006032.4	NP_006023.1	copine-6 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of dendrite extension	IDA IDA: Inferred from direct assay	23999003	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPNE6 Protein Structure

C2

Copine

0
100
200
300
400
500
557 a.a.

Protein Preferred Names	Protein Names
copine-6	N-copine

CPNE6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CPNE6	O95741	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	CPNE6	O95741	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	CPNE6	O95741	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Vertebral Artery Occlusion	Occlusion And Stenosis Of Vertebral Artery

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03108	CPNE6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CPNE6	VGNC	VGNC:71468
Felis catus	CPNE6	VGNC	VGNC:61133
Rattus norvegicus	CPNE6	RGD	RGD:1583895
Bos taurus	CPNE6	VGNC	VGNC:27662
Canis familiaris	CPNE6	VGNC	VGNC:39565
Mus musculus	CPNE6	MGD	MGI:1334445
Others	CPNE6	NCBI