2. Others Apoptosis Cytoskeleton Cell Cycle/DNA Damage
  3. Phytohormone Apoptosis Microtubule/Tubulin
  4. Glucobrassicin

Glucobrassicin is an indole-based anticancer agent and plant growth-regulating hormone. Glucobrassicin exerts its biological activity by disrupting the integrity of microtubule networks in both plant and mammalian cells. At high concentrations, Glucobrassicin inhibits seed germination and root growth; it can also specifically induce apoptosis in mammalian cancer cells and interfere with the intercellular transmission of viruses that rely on microtubules. In plants, Glucobrassicin can be catalyzed by myrosinase to release growth-regulating substances, exhibiting a concentration-dependent growth-regulating effect.

It is advisable to consider the salt form (Glucobrassicin potassium) that retains the same biological activity.

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Glucobrassicin

Glucobrassicin Chemical Structure

CAS No. : 4356-52-9

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Glucobrassicin Related Antibodies

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Description

Glucobrassicin is an indole-based anticancer agent and plant growth-regulating hormone. Glucobrassicin exerts its biological activity by disrupting the integrity of microtubule networks in both plant and mammalian cells. At high concentrations, Glucobrassicin inhibits seed germination and root growth; it can also specifically induce apoptosis in mammalian cancer cells and interfere with the intercellular transmission of viruses that rely on microtubules. In plants, Glucobrassicin can be catalyzed by myrosinase to release growth-regulating substances, exhibiting a concentration-dependent growth-regulating effect[1][2].

In Vitro

Glucobrassicin (50 μM; 30-180 min) induces time-dependent elimination of microtubules in tobacco BY-2 TuA3-GFP cells, with nearly complete loss of microtubule integrity observed after 180 min of treatment[1].
Glucobrassicin (50 μM) drastically reduces the mitotic index and disrupts all stages of mitotic microtubule organization in Nicotiana tabacum BY-2 TuA3-GFP cells[1].
Glucobrassicin (50 μM; 30-90 min) induces rapid and sustained elimination of microtubules in HeLa GFP-α-tubulin/H2B-mCherry cells[1].
Glucobrassicin (25 μM; 24 h) induces pronounced apoptosis in HeLa GFP-α-tubulin/H2B-mCherry cells after 24 h of treatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glucobrassicin Related Antibodies

Apoptosis Analysis[1]

Cell Line: HeLa Kyoto cells stably expressing enhanced GFP-tagged α-tubulin and H2B-mCherry chromatin marker
Concentration: 25 μM
Incubation Time: 24 h
Result: Induced clear apoptotic morphology, including fragmented nuclei and condensed cellular structures after 24 h treatment. Showed a more advanced apoptotic response than that induced by 1 μM colchicine (positive control).
In Vivo

Glucobrassicin (10-5-10-2 M; applied to filter paper in contact with seeds; single initial administration) exhibits concentration-dependent effects on plant growth and germination, with strong inhibition at 10-2 M and 10-3 M, reduced inhibition at 10-4 M, and occasional stimulation at 10-5 M, and inhibits clover germination to 73% of controls at the highest tested dose[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Triticum aestivum L. var. erythrosperrnum (K6RN.) MFF. "Chlumecká"; Trifolium pratense L. "red Chlumecká"; Brassica oleracea L. var. sabauda L. "Dětická latě"[2]
Dosage: 10⁻2 M; 10⁻3 M; 10⁻4 M; 10⁻5 M
Administration: applied to filter paper in contact with seeds; single initial administration
Result: Strongly inhibited growth of wheat roots (formed short, clustered roots with increased root count) and coleoptiles, as well as clover seedling growth at 10⁻2 M and 10⁻3 M. Reduced inhibitory effect at 10-4 M.
Showed occasional stimulatory effect at 10⁻5 M, especially for clover. Inhibited clover germination to 73% of control levels at 10⁻2 M, 96% at 10⁻3 M, 101% at 10⁻4 M, and 95% at 10⁻5 M.
Inhibited wheat germination at higher concentrations.
Left Savoy cabbage germination unaffected.
Inhibited Savoy cabbage growth to a lesser degree than wheat and clover, with shift from inhibition to stimulation occurring at higher concentrations.
Molecular Weight

448.47

Formula

C16H20N2O9S2
CAS No.
SMILES

O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](S/C(CC2=CNC3=CC=CC=C32)=N\OS(O)(=O)=O)[C@@H]1O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
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Glucobrassicin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glucobrassicin4356-52-9PhytohormoneApoptosisMicrotubule/Tubulin3-indolylacetonitrile (IAN)Savoy cabbage (Brassica oleracea var. sabauda)tobacco BY-2 TuA3-GFP cellsmyrosinaseHeLa GFP-α-tubulin/H2B-mCherry cellswheat (Triticum aestivum)microtubulesmammalian cancer cellsclover (Trifolium pratense)apoptosisInhibitorinhibitorinhibit

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