2. Others Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Phytohormone Microtubule/Tubulin Apoptosis
  4. Glucobrassicin potassium

Glucobrassicin potassium is an indole-based anticancer agent and plant growth-regulating hormone. Glucobrassicin potassium exerts its biological activity by disrupting the integrity of microtubule networks in both plant and mammalian cells. At high concentrations, Glucobrassicin potassium inhibits seed germination and root growth; it can also specifically induce apoptosis in mammalian cancer cells and interfere with the intercellular transmission of viruses that rely on microtubules. In plants, Glucobrassicin potassium can be catalyzed by myrosinase to release growth-regulating substances, exhibiting a concentration-dependent growth-regulating effect.

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Glucobrassicin potassium

Glucobrassicin potassium Chemical Structure

CAS No. : 143231-38-3

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Glucobrassicin potassium Related Antibodies

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Description

Glucobrassicin potassium is an indole-based anticancer agent and plant growth-regulating hormone. Glucobrassicin potassium exerts its biological activity by disrupting the integrity of microtubule networks in both plant and mammalian cells. At high concentrations, Glucobrassicin potassium inhibits seed germination and root growth; it can also specifically induce apoptosis in mammalian cancer cells and interfere with the intercellular transmission of viruses that rely on microtubules. In plants, Glucobrassicin potassium can be catalyzed by myrosinase to release growth-regulating substances, exhibiting a concentration-dependent growth-regulating effect[1][2].

In Vitro

Glucobrassicin potassium (50 μM; 30-180 min) induces time-dependent elimination of microtubules in tobacco BY-2 TuA3-GFP cells, with nearly complete loss of microtubule integrity observed after 180 min of treatment[1].
Glucobrassicin potassium (50 μM) drastically reduces the mitotic index and disrupts all stages of mitotic microtubule organization in Nicotiana tabacum BY-2 TuA3-GFP cells[1].
Glucobrassicin potassium (50 μM; 30-90 min) induces rapid and sustained elimination of microtubules in HeLa GFP-α-tubulin/H2B-mCherry cells[1].
Glucobrassicin potassium (25 μM; 24 h) induces pronounced apoptosis in HeLa GFP-α-tubulin/H2B-mCherry cells after 24 h of treatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glucobrassicin potassium Related Antibodies
In Vivo

Glucobrassicin potassium (10-5-10-2 M; applied to filter paper in contact with seeds; single initial administration) exhibits concentration-dependent effects on plant growth and germination, with strong inhibition at 10-2 M and 10-3 M, reduced inhibition at 10-4 M, and occasional stimulation at 10-5 M, and inhibits clover germination to 73% of controls at the highest tested dose[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

486.56

Formula

C16H19KN2O9S2
CAS No.
Appearance

Solid

Color

Pale purple to light pink

SMILES

OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](S/C(CC2=CNC3=C2C=CC=C3)=N\OS(=O)(O[K])=O)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (256.91 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0552 mL 10.2762 mL 20.5525 mL
5 mM 0.4110 mL 2.0552 mL 4.1105 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.0552 mL 10.2762 mL 20.5524 mL 51.3811 mL
5 mM 0.4110 mL 2.0552 mL 4.1105 mL 10.2762 mL
10 mM 0.2055 mL 1.0276 mL 2.0552 mL 5.1381 mL
15 mM 0.1370 mL 0.6851 mL 1.3702 mL 3.4254 mL
20 mM 0.1028 mL 0.5138 mL 1.0276 mL 2.5691 mL
25 mM 0.0822 mL 0.4110 mL 0.8221 mL 2.0552 mL
30 mM 0.0685 mL 0.3425 mL 0.6851 mL 1.7127 mL
40 mM 0.0514 mL 0.2569 mL 0.5138 mL 1.2845 mL
50 mM 0.0411 mL 0.2055 mL 0.4110 mL 1.0276 mL
60 mM 0.0343 mL 0.1713 mL 0.3425 mL 0.8564 mL
80 mM 0.0257 mL 0.1285 mL 0.2569 mL 0.6423 mL
100 mM 0.0206 mL 0.1028 mL 0.2055 mL 0.5138 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glucobrassicin143231-38-3PhytohormoneMicrotubule/TubulinApoptosisglucosinolate (GSL)weed managementInhibitorinhibitorinhibit

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