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Cat. No.: HY-155112

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Antiproliferative agent-30

Antiproliferative agent-30 (Compound 8g) inhibits tubulin assembly and inhibits FLT3 and Abl1. Antiproliferative agent-30 has vascular-disrupting activity. Antiproliferative agent-30 has broad antiproliferative activities against cancer cell lines (IC₅₀s: 0.054 nM, 0.008 nM, 0.144 nM for HCT-116, K562, MV-4-11 cells respectively). Antiproliferative agent-30 also has anticancer effect against AML with FLT3-ITD-TKD mutation.

For research use only. We do not sell to patients.

CAS No.: 2713553-88-7
Formula: C₂₄H₂₆N₄O₄
Molecular Weight:434.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Antiproliferative agent-30 Chemical Structure

CAS No.: 2713553-88-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

All Bcr-Abl Isoforms :

Abl
Bcr-Abl

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.169 nM Compound: 8g	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 37544183]
A549/TR	IC₅₀	168 nM Compound: 8g	Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 37544183]
HCT-116	IC₅₀	0.054 nM Compound: 8g	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 37544183]
HT-29	IC₅₀	7.985 nM Compound: 8g	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 37544183]
K562	IC₅₀	0.008 nM Compound: 8g	Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 37544183]
K562/Adr	IC₅₀	693 nM Compound: 8g	Antiproliferative activity against human K562/Adr cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human K562/Adr cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 37544183]
MCF7	IC₅₀	123.777 nM Compound: 8g	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 37544183]
MDA-MB-231	IC₅₀	25.137 nM Compound: 8g	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 37544183]
MOLT-4	IC₅₀	6.794 nM Compound: 8g	Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 37544183]
MV4-11	IC₅₀	0.144 nM Compound: 8g	Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 37544183]
MV4-11	IC₅₀	0.144 nM Compound: 8g	Antiproliferative activity against human MV4-11 cells transfected with FLT3-ITD mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human MV4-11 cells transfected with FLT3-ITD mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 37544183]
PANC-1	IC₅₀	224.867 nM Compound: 8g	Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 37544183]
PLC-PRF-5	IC₅₀	21.553 nM Compound: 8g	Antiproliferative activity against human PLC-PRF-5 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human PLC-PRF-5 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 37544183]
THP-1	IC₅₀	77.953 nM Compound: 8g	Antiproliferative activity against human THP-1 cells transfected with wild type FLT3 assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human THP-1 cells transfected with wild type FLT3 assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 37544183]

Chemical Information

CAS No. 2713553-88-7
Molecular Weight 434.49
Formula C₂₄H₂₆N₄O₄
SMILES

CC1=C(NCCO)C=C(C2=CN=C3C(C(C4=CC(OC)=C(OC)C(OC)=C4)=NN3)=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chengqing Ning, et al. Design, synthesis, and biological evaluation of 3, 5-disubsituted-1H-pyrazolo[3,4-b]pyridines as multiacting inhibitors against microtubule and kinases. European Journal of Medicinal Chemistry. Volume 259, 5 November 2023, 115687.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Antiproliferative agent-30

All Bcr-Abl Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Antiproliferative agent-30 Related Classifications

HY-155112 Related Classifications