2713553-88-7
Chemical Structure
Antiproliferative agent-30
- CAS No.: 2713553-88-7
- Formula:C24H26N4O4
- Molecular Weight:434.49
InChIKey: OATHVDKMFZZHHN-UHFFFAOYSA-N
SMILES: CC1=C(NCCO)C=C(C2=CN=C3C(C(C4=CC(OC)=C(OC)C(OC)=C4)=NN3)=C2)C=C1
Biological Activity: Antiproliferative agent-30 (Compound 8g) inhibits tubulin assembly and inhibits FLT3 and Abl1. Antiproliferative agent-30 has vascular-disrupting activity. Antiproliferative agent-30 has broad antiproliferative activities against cancer cell lines (IC50s: 0.054 nM, 0.008 nM, 0.144 nM for HCT-116, K562, MV-4-11 cells respectively). Antiproliferative agent-30 also has anticancer effect against AML with FLT3-ITD-TKD mutation[1].
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Antiproliferative agent-30 | Antiproliferative agent-30 (Compound 8g) inhibits tubulin assembly and inhibits FLT3 and Abl1. Antiproliferative agent-30 has vascular-disrupting activity. Antiproliferative agent-30 has broad antiproliferative activities against cancer cell lines (IC50s: 0.054 nM, 0.008 nM, 0.144 nM for HCT-116, K562, MV-4-11 cells respectively). Antiproliferative agent-30 also has anticancer effect against AML with FLT3-ITD-TKD mutation. | |||||||||||||||||||||
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Keywords
