METTL14 - methyltransferase 14, N6-adenosine-methyltransferase subunit Gene

Also Known as hMETTL14

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57721

About METTL14

Cytogenetic location: 4q26 Genomic coordinates (GRCh38): 4:118,685,392-118,715,430 (from NCBI)

This gene has 6 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in testis (RPKM 8.4), thyroid (RPKM 7.2) and 25 other tissues.

Summary

Enables mRNA binding activity. Contributes to mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity. Involved in mRNA metabolic process; negative regulation of hematopoietic progenitor cell differentiation; and positive regulation of translation. Located in nucleoplasm. Part of RNA N6-methyladenosine methyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

METTL14 Products (1)

mRNA Protein Name
NM_020961.4 NP_066012.1 N6-adenosine-methyltransferase non-catalytic subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables S-adenosyl-L-methionine binding IDA
IDA: Inferred from direct assay
27281194 GOA
enables mRNA binding IDA
IDA: Inferred from direct assay
27281194 GOA
NOT enables mRNA m(6)A methyltransferase activity IDA
IDA: Inferred from direct assay
27627798 GOA
enables mRNA m(6)A methyltransferase activity IDA
IDA: Inferred from direct assay
24316715 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24316715 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA modification IDA
IDA: Inferred from direct assay
27281194 GOA
involved in mRNA processing IDA
IDA: Inferred from direct assay
27281194 GOA
involved in mRNA processing IMP
IMP: Inferred from mutant phenotype
24316715 GOA
involved in mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
25719671 GOA
involved in mRNA stabilization IDA
IDA: Inferred from direct assay
29290617 GOA
acts upstream of negative regulation of hematopoietic progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
29290617 GOA
acts upstream of positive regulation of translation IMP
IMP: Inferred from mutant phenotype
29290617 GOA
Cellular Component GO Annotation Evidence References Source
part of RNA N6-methyladenosine methyltransferase complex IDA
IDA: Inferred from direct assay
24316715 GOA
part of RNA N6-methyladenosine methyltransferase complex IPI
IPI: Inferred from physical interaction
29507755 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24316715 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL14 Protein Structure

MT-A70

MT-A70: MT-A70 (186 - 362)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 456 a.a.
Protein Preferred Names Protein Names

N6-adenosine-methyltransferase non-catalytic subunit

  • N6-adenosine-methyltransferase subunit METTL14

METTL14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
METTL14 Q9HCE5 METTL3 Homo sapiens Q86U44
GMS
27373337
Intra
METTL14 Q9HCE5 METTL3 Homo sapiens Q86U44
Comig Non-Denat Gel
24316715
Intra
METTL14 Q9HCE5 METTL3 Homo sapiens Q86U44
Pull Down
24394384
Intra
METTL14 Q9HCE5 METTL3 Homo sapiens Q86U44
Anti Tag CoIP
33961781
Intra
METTL14 Q9HCE5 METTL3 Homo sapiens Q86U44
Anti Tag CoIP
24316715
Intra
METTL14 Q9HCE5 METTL3 Homo sapiens Q86U44
Anti Tag CoIP
29507755
Intra
METTL14 Q9HCE5 METTL3 Homo sapiens Q86U44
X-Ray Diffraction
27373337
Intra
METTL14 Q9HCE5 METTL3 Homo sapiens Q86U44-1
Anti Tag CoIP
24316715
Intra
METTL14 Q9HCE5 METTL3 Homo sapiens Q86U44-1
GMS
24316715
Intra
METTL14 Q9HCE5 WTAP Homo sapiens Q15007-1
Anti Tag CoIP
24316715
Intra
METTL14 Q9HCE5 WTAP Homo sapiens Q15007-1
GMS
24316715
Cross: Cross-species interaction Intra: Intraspecies interaction

METTL14 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86961 METTL14 Antibody (YA6654) WB, ICC/IF, IHC-P, FC, IP Human, Mouse, Rat, Monkey

Related Diseases

Diseases Alias
Hepatoblastoma
Wilms Tumor 1

  • Nephroblastoma

  • Wilms Tumor

  • WT1

  • Wilms' Tumor

  • Bilateral Wilms Tumor

  • Wilms Tumor, Type 1

  • Wilms Tumor, Somatic

  • Adult Nephroblastoma

  • Wt1 Disorder

  • Renal Embryonic Tumor

  • Adult Kidney Wilms Tumor

  • Childhood Kidney Wilms Tumor

  • Nonanaplastic Kidney Wilms Tumor
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19528 SAH 99.90% Unkown
HY-160415A WD6305 TFA 99.81% Unkown
HY-W037893 CHMA1004 dihydrochloride Activator 99.38% Unkown
HY-N0353 Curdione Inhibitor 99.80% Unkown
HY-19528S SAH-d4 ≥99.0% Unkown
HY-160415 WD6305 98.98% Unkown
HY-P10387 RSM3 95.73% Unkown
HY-RS08355 METTL14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-153625 STM2120 Inhibitor 99.19% Unkown
HY-P10387A RSM3 TFA 98.83% Unkown
HY-RS16861 Mettl14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-151926 Antiviral agent 24 Inhibitor 99.63% Unkown
HY-162930 PROTAC METTL3 degrader 1 Degrader / Unkown
HY-19528S2 SAH-13C10 99.90% Unkown
HY-183186 EP102 Inhibitor / Unkown
HY-151924 Antiviral agent 23 Inhibitor / Unkown
HY-162282 PROTAC METTL3-14 degrader 1 Degrader / Unkown
HY-W125425 CHMA1004 Activator / Unkown
HY-RS23302 Mettl14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus METTL14 VGNC VGNC:63459
Canis familiaris METTL14 VGNC VGNC:43171
Macaca mulatta METTL14 VGNC VGNC:74612
Mus musculus METTL14 MGD MGI:2442926
Bos taurus METTL14 VGNC VGNC:31404
Rattus norvegicus METTL14 RGD RGD:1304822
Others METTL14 NCBI