Ingenol-3-palmitate
Based on 1 Customer Validation
Ingenol-3-palmitate, an ingenane diterpenoid, is a nature product that could be isolated from the roots of Euphorbia ebracteolata. Ingenol-3-palmitate is a potent HIV-1 (HIV) inhibitor with an IC50 value of 4.1 nM.
For research use only. We do not sell to patients.
- Purity: 99.65%
- CAS No.: 52557-26-3
- Formula: C36H58O6
- Molecular Weight:586.84
-
Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
HIV-1 4.1 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Keratinocyte | EC50 |
7.3 nM
Compound: 41
|
Induction of IL-8 release in human primary epidermal keratinocytes after 6 hrs by HTRF assay
Induction of IL-8 release in human primary epidermal keratinocytes after 6 hrs by HTRF assay
|
[PMID: 23993332] |
| Keratinocyte | EC50 |
8.4 nM
Compound: 41
|
Induction of TNFalpha release in human primary epidermal keratinocytes after 6 hrs
Induction of TNFalpha release in human primary epidermal keratinocytes after 6 hrs
|
[PMID: 23993332] |
| MT4 | CC50 |
26.3 μM
Compound: 4
|
Cytotoxicity against human MT4 cells measured after 3 days by CytoTox-Glo assay
Cytotoxicity against human MT4 cells measured after 3 days by CytoTox-Glo assay
|
[PMID: 31184480] |
Chemical Information
-
CAS No. 52557-26-3
-
Appearance Oil
-
Molecular Weight 586.84
-
Formula C36H58O6
-
Color Colorless to light yellow
-
SMILES
O[C@@]12[C@]3(C=C([C@@H]2OC(CCCCCCCCCCCCCCC)=O)C)C([C@](C=C([C@H]1O)CO)([H])[C@@]4([H])[C@@](C4(C)C)([H])C[C@H]3C)=O
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (85.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
-
Data Sheet (270 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7040 mL | 8.5202 mL | 17.0404 mL | 42.6010 mL |
| 5 mM | 0.3408 mL | 1.7040 mL | 3.4081 mL | 8.5202 mL | |
| 10 mM | 0.1704 mL | 0.8520 mL | 1.7040 mL | 4.2601 mL | |
| 15 mM | 0.1136 mL | 0.5680 mL | 1.1360 mL | 2.8401 mL | |
| 20 mM | 0.0852 mL | 0.4260 mL | 0.8520 mL | 2.1301 mL | |
| 25 mM | 0.0682 mL | 0.3408 mL | 0.6816 mL | 1.7040 mL | |
| 30 mM | 0.0568 mL | 0.2840 mL | 0.5680 mL | 1.4200 mL | |
| 40 mM | 0.0426 mL | 0.2130 mL | 0.4260 mL | 1.0650 mL | |
| 50 mM | 0.0341 mL | 0.1704 mL | 0.3408 mL | 0.8520 mL | |
| 60 mM | 0.0284 mL | 0.1420 mL | 0.2840 mL | 0.7100 mL | |
| 80 mM | 0.0213 mL | 0.1065 mL | 0.2130 mL | 0.5325 mL |
Ingenol-3-palmitate Related Classifications
HY-137242 Related Classifications
Powered by Bioz