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RUNDC3A - RUN domain containing 3A Gene

Also Known as RPIP8; RAP2IP; RPIP-8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10900

About RUNDC3A

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:44,308,601-44,318,670 (from NCBI)

This gene has 7 transcripts (splice variants), 267 orthologues and 13 paralogues. Biased expression in brain (RPKM 51.0), adrenal (RPKM 6.3) and 1 other tissue.

Summary

Predicted to enable GTPase regulator activity. Predicted to be involved in positive regulation of cGMP-mediated signaling. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]

RUNDC3A Products (3)

mRNA	Protein	Name
NM_001144825.2	NP_001138297.1	RUN domain-containing protein 3A isoform 1
NM_001144826.2	NP_001138298.1	RUN domain-containing protein 3A isoform 3
NM_006695.5	NP_006686.1	RUN domain-containing protein 3A isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RUNDC3A Protein Structure

RUN

0
100
200
300
400
446 a.a.

Protein Preferred Names	Protein Names
RUN domain-containing protein 3A	RaP2 interacting protein 8

RUNDC3A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RUNDC3A	Q59EK9	TFPT	Homo sapiens	P0C1Z6-2	Validated Y2H	25416956
Intra	RUNDC3A	Q59EK9	TFPT	Homo sapiens	P0C1Z6-2	Y2H Prey Pooling	25416956
Intra	RUNDC3A	Q59EK9	TBRG1	Homo sapiens	Q05BL0	Validated Y2H	25416956
Intra	RUNDC3A	Q59EK9	TBRG1	Homo sapiens	Q05BL0	Y2H Array	25416956
Intra	RUNDC3A	Q59EK9	TBRG1	Homo sapiens	Q05BL0	Y2H Prey Pooling	25416956
Intra	RUNDC3A	Q59EK9	q9h614_human	Homo sapiens	Q9H614	Y2H Array	25416956
Intra	RUNDC3A	Q59EK9	CCNL2	Homo sapiens	Q96S94	Y2H Array	25416956
Intra	RUNDC3A	Q59EK9	MRPL15	Homo sapiens	Q9P015	Y2H Array	25416956
Intra	RUNDC3A	Q59EK9	AP2M1	Homo sapiens	Q96CW1	Anti Tag CoIP	33961781
Intra	RUNDC3A	Q59EK9	EIF3E	Homo sapiens	P60228	Y2H Array	25416956
Intra	RUNDC3A	Q59EK9	DDX6	Homo sapiens	P26196	Validated Y2H	25416956
Intra	RUNDC3A	Q59EK9	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	25416956
Intra	RUNDC3A	Q59EK9	AP1M1	Homo sapiens	Q9BXS5	Y2H Prey Pooling	25416956
Intra	RUNDC3A	Q59EK9	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	25416956
Intra	RUNDC3A	Q59EK9	ZNF587	Homo sapiens	Q96SQ5	Y2H Prey Pooling	25416956
Intra	RUNDC3A	Q59EK9	FAM161A	Homo sapiens	Q3B820	Y2H Array	25416956
Intra	RUNDC3A	Q59EK9	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	RUNDC3A	Q59EK9	SDCBP	Homo sapiens	O00560	Y2H Array	25416956
Intra	RUNDC3A	Q59EK9	ZNF417	Homo sapiens	Q8TAU3	Y2H Array	25416956
Intra	RUNDC3A	Q59EK9	ZNF417	Homo sapiens	Q8TAU3	Y2H Prey Pooling	25416956
Intra	RUNDC3A	Q59EK9	ARMC7	Homo sapiens	Q9H6L4	Y2H Array	25416956
Intra	RUNDC3A	Q59EK9	ARMC7	Homo sapiens	Q9H6L4	Y2H Prey Pooling	25416956
Intra	RUNDC3A	Q59EK9	GEM	Homo sapiens	P55040	Validated Y2H	25416956
Intra	RUNDC3A	Q59EK9	GEM	Homo sapiens	P55040	Y2H Array	25416956
Intra	RUNDC3A	Q59EK9	SYT17	Homo sapiens	Q9BSW7	Validated Y2H	25416956
Intra	RUNDC3A	Q59EK9	SYT17	Homo sapiens	Q9BSW7	Y2H Array	25416956
Intra	RUNDC3A	Q59EK9	MAGOHB	Homo sapiens	Q96A72	Validated Y2H	25416956
Intra	RUNDC3A	Q59EK9	MAGOHB	Homo sapiens	Q96A72	Y2H Array	25416956
Intra	RUNDC3A	Q59EK9	RAP2B	Homo sapiens	P61225	Validated Y2H	25416956
Intra	RUNDC3A	Q59EK9	MAGEB4	Homo sapiens	O15481	Y2H Array	25416956
Intra	RUNDC3A	Q59EK9	MAGEB4	Homo sapiens	O15481	Y2H Prey Pooling	25416956
Intra	RUNDC3A	Q59EK9	MAGEB4	Homo sapiens	O15481	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Malignant Pineal Area Germ Cell Neoplasm	Pineal Germ Cell Tumor Malignant Pineal Parenchymal Germ Cell Tumor Pineal Region Germ Cell Tumor Pineal Cell Tumor Pineal Cell Tumour Pineal Region Germinoma Malignant Pineal Region Germ Cell Tumor Pineal Germinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12348	RUNDC3A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RUNDC3A	RGD	RGD:735057
Macaca mulatta	RUNDC3A	VGNC	VGNC:77032
Bos taurus	RUNDC3A	VGNC	VGNC:34218
Mus musculus	RUNDC3A	MGD	MGI:1858752
Canis familiaris	RUNDC3A	VGNC	VGNC:45807
Felis catus	RUNDC3A	VGNC	VGNC:64822
Others	RUNDC3A	NCBI