CCNL2 - cyclin L2 Gene

Also Known as CCNM; CCNS; PCEE; SB138; ANIA-6B; HLA-ISO; HCLA-ISO

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81669

About CCNL2

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,385,711-1,399,335 (from NCBI)

This gene has 19 transcripts (splice variants), 145 orthologues and 6 paralogues. Ubiquitous expression in skin (RPKM 45.3), endometrium (RPKM 44.2) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing Apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

CCNL2 Products (8)

mRNA Protein Name
NM_001039577.5 NP_001034666.1 cyclin-L2 isoform B
NM_001320153.3 NP_001307082.1 cyclin-L2 isoform C
NM_001320155.3 NP_001307084.1 cyclin-L2 isoform C
NM_001350497.1 NP_001337426.1 cyclin-L2 isoform C
NM_001350498.2 NP_001337427.1 cyclin-L2 isoform C
NM_001350499.2 NP_001337428.1 cyclin-L2 isoform D
NM_001350500.2 NP_001337429.1 cyclin-L2 isoform D
NM_030937.6 NP_112199.2 cyclin-L2 isoform A
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of RNA splicing IDA
IDA: Inferred from direct assay
18216018 GOA
Cellular Component GO Annotation Evidence References Source
part of cyclin-dependent protein kinase holoenzyme complex IPI
IPI: Inferred from physical interaction
18216018 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17494991 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCNL2 Protein Structure

Cyclin_N

Cyclin_N: Cyclin, N-terminal domain (72 - 191)

Cyclin_C

Cyclin_C: Cyclin, C-terminal domain (215 - 288)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 520 a.a.
Protein Preferred Names Protein Names

cyclin-L2

  • cyclin M

CCNL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CCNL2 Q96S94 RUNDC3A Homo sapiens Q59EK9 25416956
Intra
CCNL2 Q96S94 RUNDC3A Homo sapiens Q59EK9 25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations
  • Star Syndrome

  • Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome

  • Syndactyly With Renal And Anogenital Malformations

  • STAR

  • Syndactyly, Telecanthus, Anogenital And Renal Malformations

  • Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations

Jalili Syndrome
  • Cone-Rod Dystrophy And Amelogenesis Imperfecta

  • Cone Rod Dystrophy-Amelogenesis Imperfecta Syndrome

  • Cone-Rod Dystrophy Amelogenesis Imperfecta

  • Cone-Rod Dystrophy With Amelogenesis Imperfecta

  • JALIS

  • Cone Rod Dystrophy Amelogenesis Imperfecta

Noonan Syndrome 1
  • Noonan Syndrome

  • NS1

  • Male Turner Syndrome

  • Female Pseudo-Turner Syndrome

  • Turner Phenotype With Normal Karyotype

  • Noonan Syndrome With Pigmented Villonodular Synovitis

  • Turner'S Phenotype, Karyotype Normal

  • Familial Turner Syndrome

  • Noonan'S Syndrome

  • Noonan-Ehmke Syndrome

  • Ns

  • Pseudo-Ullrich-Turner Syndrome

  • Turner Syndrome In Female With X Chromosome

  • Turner-Like Syndrome

  • Ullrich-Noonan Syndrome

  • Noonan-Like/Multiple Giant Cell Lesion Syndrome

  • Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

  • Pterygium Colli Syndrome

  • Noonan Syndrome, Type 1

  • Turner Syndrome, Male

Townes-Brocks Syndrome
  • Townes Syndrome

  • Renal-Ear-Anal-Radial Syndrome

  • Anus, Imperforate, With Hand, Foot And Ear Anomalies

  • Imperforate Anus-Hand, Foot And Ear Anomalies Syndrome

  • Rear Syndrome

  • Sensorineural Deafness With Imperforate Anus And Hypoplastic Thumbs

  • Tbs

  • Deafness, Sensorineural, With Imperforate Anus And Hypoplastic Thumbs

  • Imperforate Anus With Hand, Foot And Ear Anomalies

  • Anal-Ear-Renal-Radial Malformation Syndrome

  • Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome

  • Imperforate Anus-Hand And Foot Anomalies Syndrome

  • Sensorineural Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome

  • Sensorineural Hearing Loss With Imperforate Anus And Hypoplastic Thumbs

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus CCNL2 VGNC VGNC:80161
Canis familiaris CCNL2 VGNC VGNC:38905
Bos taurus CCNL2 VGNC VGNC:26976
Rattus norvegicus CCNL2 RGD RGD:1309149
Mus musculus CCNL2 MGD MGI:1927119
Others CCNL2 NCBI