1. Gene
  2. CCNL2 - cyclin L2 Gene

CCNL2 - cyclin L2 Gene

Homo sapiens

Also known as CCNM; CCNS; PCEE; SB138; ANIA-6B; HLA-ISO; HCLA-ISO

Gene ID: 81669 | Gene type: protein coding

About CCNL2

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,385,711-1,399,335 (from NCBI)

This gene has 19 transcripts (splice variants), 145 orthologues and 6 paralogues. Ubiquitous expression in skin (RPKM 45.3), endometrium (RPKM 44.2) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing Apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

CCNL2 Products(8)

mRNA Protein Name
NM_001039577.5 NP_001034666.1 cyclin-L2 isoform B
NM_001320153.3 NP_001307082.1 cyclin-L2 isoform C
NM_001320155.3 NP_001307084.1 cyclin-L2 isoform C
NM_001350497.1 NP_001337426.1 cyclin-L2 isoform C
NM_001350498.2 NP_001337427.1 cyclin-L2 isoform C
NM_001350499.2 NP_001337428.1 cyclin-L2 isoform D
NM_001350500.2 NP_001337429.1 cyclin-L2 isoform D
NM_030937.6 NP_112199.2 cyclin-L2 isoform A

CCNL2 Protein Structure

Cyclin_N

Cyclin_N: Cyclin, N-terminal domain (72 - 191)

Cyclin_C

Cyclin_C: Cyclin, C-terminal domain (215 - 288)

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  • 520 a.a.
Protein Preferred Names Protein Names

cyclin-L2

cyclin M

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STAR

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Sensorineural Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome

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Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

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Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

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Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus CCNL2 VGNC VGNC:80161
Canis familiaris CCNL2 VGNC VGNC:38905
Bos taurus CCNL2 VGNC VGNC:26976
Rattus norvegicus CCNL2 RGD RGD:1309149
Mus musculus CCNL2 MGD MGI:1927119