CCNL2 - cyclin L2 Gene
Also Known as CCNM; CCNS; PCEE; SB138; ANIA-6B; HLA-ISO; HCLA-ISO
Species: Homo sapiens
About CCNL2
This gene has 19 transcripts (splice variants), 145 orthologues and 6 paralogues. Ubiquitous expression in skin (RPKM 45.3), endometrium (RPKM 44.2) and 25 other tissues.
Summary
The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing Apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
CCNL2 Products (8)
| mRNA | Protein | Name |
|---|---|---|
| NM_001039577.5 | NP_001034666.1 | cyclin-L2 isoform B |
| NM_001320153.3 | NP_001307082.1 | cyclin-L2 isoform C |
| NM_001320155.3 | NP_001307084.1 | cyclin-L2 isoform C |
| NM_001350497.1 | NP_001337426.1 | cyclin-L2 isoform C |
| NM_001350498.2 | NP_001337427.1 | cyclin-L2 isoform C |
| NM_001350499.2 | NP_001337428.1 | cyclin-L2 isoform D |
| NM_001350500.2 | NP_001337429.1 | cyclin-L2 isoform D |
| NM_030937.6 | NP_112199.2 | cyclin-L2 isoform A |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
25416956 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in regulation of RNA splicing |
IDA
IDA: Inferred from direct assay
|
18216018 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of cyclin-dependent protein kinase holoenzyme complex |
IPI
IPI: Inferred from physical interaction
|
18216018 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
17494991 | GOA |
CCNL2 Protein Structure
Cyclin_N: Cyclin, N-terminal domain (72 - 191)
Cyclin_C: Cyclin, C-terminal domain (215 - 288)
- 0
- 100
- 200
- 300
- 400
- 520 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
cyclin-L2 |
|
CCNL2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CCNL2 | Q96S94 | RUNDC3A | Homo sapiens | Q59EK9 | 25416956 | |
|
Intra
|
CCNL2 | Q96S94 | RUNDC3A | Homo sapiens | Q59EK9 | 25416956 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations |
|
|
| Jalili Syndrome |
|
|
| Noonan Syndrome 1 |
|
|
| Townes-Brocks Syndrome |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | CCNL2 | VGNC | VGNC:80161 |
| Canis familiaris | CCNL2 | VGNC | VGNC:38905 |
| Bos taurus | CCNL2 | VGNC | VGNC:26976 |
| Rattus norvegicus | CCNL2 | RGD | RGD:1309149 |
| Mus musculus | CCNL2 | MGD | MGI:1927119 |
| Others | CCNL2 | NCBI |