Gnrhr - gonadotropin releasing hormone receptor Gene

Also Known as GH1; Lhrhr

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81668

About Gnrhr

Primary_assembly 14: 21,856,871-21,874,861 forward strand.mRatBN7.2:CM026987.1

This gene has 1 transcript (splice variant), 241 orthologues, 16 paralogues and is associated with 9 phenotypes. Biased expression in Testes (RPKM 82.5), Adrenal (RPKM 42.5) and 1 other tissue.

Summary

Enables growth hormone-releasing hormone receptor activity. Involved in G protein-coupled receptor signaling pathway; circadian rhythm; and negative regulation of cell population proliferation. Located in plasma membrane. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 7 with or without anosmia. Orthologous to human GNRHR (gonadotropin releasing hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]

Gnrhr Products (1)

mRNA Protein Name
NM_031038.3 NP_112300.2 gonadotropin-releasing hormone receptor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables growth hormone-releasing hormone receptor activity IDA
IDA: Inferred from direct assay
12050161 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17170088 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
12050161 RGD
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
22356123 RGD
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
14551223 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gnrhr Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (35 - 326)

7tm_GPCRs

7tm_GPCRs: cd14964 (37 - 66)

7tm_GPCRs

7tm_GPCRs: cd14964 (76 - 99)

7tm_GPCRs

7tm_GPCRs: cd14964 (114 - 136)

7tm_GPCRs

7tm_GPCRs: cd14964 (157 - 173)

7tm_GPCRs

7tm_GPCRs: cd14964 (207 - 230)

7tm_GPCRs

7tm_GPCRs: cd14964 (264 - 286)

7tm_GPCRs

7tm_GPCRs: cd14964 (300 - 325)

  • 0
  • 100
  • 200
  • 300
  • 327 a.a.
Protein Preferred Names Protein Names

gonadotropin-releasing hormone receptor

  • gnRH receptor

  • gnRH-R

  • growth hormone

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0009A Cetrorelix acetate 99.98% Unkown
HY-P0009 Cetrorelix 99.71% Yes
HY-16168B Degarelix acetate hydrate / Unkown

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W041308 DCOIT Agonist 99.87% Unkown
HY-133080 BAY-784 Antagonist 99.5% Unkown
HY-151247 GnRH-R antagonist 1 Antagonist / Unkown
HY-12096 WAY-207024 Antagonist / Unkown
HY-12096A WAY-207024 dihydrochloride Agonist / Unkown
HY-14369S Elagolix-13C,d3 sodium Antagonist / Unkown
HY-16168AS Degarelix-d7 Antagonist / Unkown
HY-178418 GnRH-R antagonist-2 Antagonist / Unkown
HY-178419 GnRH-R antagonist-3 Antagonist / Unkown
HY-P11265 YQGN-7 / Unkown
HY-RS05578 GNRHR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05579 Gnrhr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05580 Gnrhr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-117982 SKI2496 / Unkown
HY-P0009S1 Cetrorelix-d10 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gnrhr NCBI NCBI:2798