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Cat. No.: HY-12096

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WAY-207024

WAY-207024 is an orally active gonadotropin releasing hormone receptor (GnRH-R) antagonist (human GnRH: IC₅₀ of 12 nM, rat GnRH: IC₅₀ of 71 nM). WAY-207024 inhibits rat LH release with an IC₅₀ of 350 nM. WAY-207024 lowers rat plasma leuteinizing hormone (LH) levels after oral administration.

For research use only. We do not sell to patients.

CAS No.: 872002-72-7
Formula: C₃₀H₃₂N₆
Molecular Weight:476.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

WAY-207024 Chemical Structure

CAS No.: 872002-72-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Human GnRH

12 nM (IC₅₀)

Rat GnRH

71 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
Pituitary gland cell	IC₅₀	0.36 μM Compound: 1	Antagonist activity at GNRH receptor in rat pituitary cells assessed as inhibition of D-Trp6-GnRH-induced LH accumulation after 3 hrs by RIA Antagonist activity at GNRH receptor in rat pituitary cells assessed as inhibition of D-Trp6-GnRH-induced LH accumulation after 3 hrs by RIA	[PMID: 20236823]
Pituitary gland cell	IC₅₀	320 nM Compound: 6, WAY-207024	Antagonist activity at rat recombinant GnRH receptor assessed as inhibition of [D-Trp6]-GnRH-stimulated LH release from rat pituitary cells Antagonist activity at rat recombinant GnRH receptor assessed as inhibition of [D-Trp6]-GnRH-stimulated LH release from rat pituitary cells	[PMID: 19271735]

Chemical Information

CAS No. 872002-72-7
Molecular Weight 476.62
Formula C₃₀H₃₂N₆
SMILES

CC(C1=CC=C(C2=NC3=CC=CC(N4CCN(CC5=CC=C6N=CC=NC6=C5)CC4)=C3N2)C=C1)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jeffrey C Pelletier, et al. Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R). J Med Chem. 2009 Apr 9;52(7):2148-52. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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