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Cat. No.: HY-P1018

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IRL 1038

IRL 1038 is an endothelin B receptor selective antagonist with a K_i of 6-11 nM.

For research use only. We do not sell to patients.

CAS No.: 144602-02-8
Formula: C₆₈H₉₂N₁₄O₁₅S₂
Molecular Weight:1409.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

IRL 1038 Chemical Structure

CAS No.: 144602-02-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IRL 1038 is an endothelin B receptor selective antagonist with a K_i of 6-11 nM^[1].

IC₅₀ & Target

Ki: 6-11 nM (endothelin B receptors), 0.4-0.7 μM (endothelin A receptors)^[1]

All Endothelin Receptor Isoforms :

ET_A
ET_B

Chemical Information

CAS No. 144602-02-8
Molecular Weight 1409.67
Formula C₆₈H₉₂N₁₄O₁₅S₂
Sequence

Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridge:Cys1-Cys5)
Sequence Shortening

CVYFCHLDIIW (Disulfide bridge:Cys1-Cys5)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Urade Y, et al. An endothelin B receptor-selective antagonist: IRL 1038, [Cys11-Cys15]-endothelin-1(11-21). FEBS Lett. 1992 Oct 12;311(1):12-6. doi: 10.1016/0014-5793(92)81355-p. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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IRL 1038

All Endothelin Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

IRL 1038 Related Classifications

HY-P1018 Related Classifications