Ac2-26 TFA
Based on 8 publication(s) in Google Scholar
Ac2-26 TFA is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ameliorates lung ischemia-reperfusion injury. Ac2-26 also inhibits airway inflammation and hyperresponsiveness in an asthma rat model.
For research use only. We do not sell to patients.
- Purity: 98.09%
- Formula: C143H211F3N32O46S.xC2HF3O2
- Molecular Weight:3203.45 (free base)
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ac2-26 TFA
More- Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]
- Cancer Cell. 2023 May 8;41(5):903-918.e8. [Abstract]
- Nat Nanotechnol. 2025 Aug 11. [Abstract]
- Mater Today Bio. 2025 Mar 20:32:101690. [Abstract]
- World J Gastroenterol. 2023 Jun 14;29(22):3422-3439. [Abstract]
- iScience. 2023 Oct 6;26(11):108153. [Abstract]
- Exp Cell Res. 2026 Jan 1;454(1):114825. [Abstract]
- Biol Reprod. 2025 Mar 26:ioaf060. [Abstract]
Customer Validation & Images
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WB
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RT-PCR
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Cell Imaging/Staining
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In Vivo Efficacy Study
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In Vivo Efficacy Study
Biological Activity
Ac2-26 (0.5 μM, 24 h) inhibits the production of infammatory cytokines and apoptosis in LPS-induced HK-2 cells[5]. Ac2-26 (1 μM, 48 h) increases rat cardiomyocyte expression of rFprs and prevents cell injury[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 3203.45 (free base)
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Formula C143H211F3N32O46S.xC2HF3O2
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Color White to off-white
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Sequence
Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys
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Sequence Shortening
Ac-AMVSEFLKQAWFIENEEQEYVQTVK
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (8)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
2024 Aug 23;9(1):218. PMID: 39174522
Ac2-26 TFA purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]
Ac2-26 (0.1 mg/mL; 48 h) significantly reduced SMAD4 protein levels in SVFs.
Ac2-26 TFA purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]
Ac2-26 (0.1 mg/mL; 48 h) significantly decreased mRNA levels of key genes in adipogenesis of SVFs.
Ac2-26 TFA purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]
Ac2-26 (0.1 mg/mL; 48 h) significantly reduced the induced differentiation potential of SVFs.
Ac2-26 TFA purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]
Ac2-26 (2 mg/kg; i.p.; every other day for 10 weeks) significantly decreased the blood glucose, TC, and TG levels in 8-week-old db/db mice fed with HFD.
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Cancer Cell
2023 May 8;41(5):903-918.e8. PMID: 36963399
Ac2-26 TFA purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2023 May 8;41(5):903-918.e8. [Abstract]
Ac2-26 (100 mg; i.p.; 3 times a week for 5 weeks) significantly reduced the tumor burdens in ESCC (esophageal squamous-cell carcinoma) mice induced by the carcinogen 4-NQO.
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Nat Nanotechnol
Annexin A1 mRNA-loaded liposomes alleviate acute pancreatitis by suppressing STING pathway and promoting efferocytosis in macrophages. [Abstract]2025 Aug 11. PMID: 40789923 -
Mater Today Bio
Peptide loaded self-healing hydrogel promotes diabetic skin wound healing through macrophage orchestration and inflammation inhibition. [Abstract]2025 Mar 20:32:101690. PMID: 40225136 -
World J Gastroenterol
Mechanism of annexin A1/N-formylpeptide receptor regulation of macrophage function to inhibit hepatic stellate cell activation through Wnt/β-catenin pathway. [Abstract]2023 Jun 14;29(22):3422-3439. PMID: 37389234 -
iScience
2023 Oct 6;26(11):108153. PMID: 37867938 -
Exp Cell Res
2026 Jan 1;454(1):114825. PMID: 41241173 -
Biol Reprod
2025 Mar 26:ioaf060. PMID: 40143407
Solvent & Solubility
H2O : 33.33 mg/mL (adjust pH to 9 with NH3·H2O)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 1 mg/mL; Clear solution; Need ultrasonic and adjust pH to 9 with NaOH
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Wang LM, et al. Annexin 1-derived peptide Ac2-26 inhibits eosinophil recruitment in vivo via decreasing prostaglandin D₂. Int Arch Allergy Immunol. 2011;154(2):137-48. [Content Brief]
[2]. Liu L, et al. Ac2-26 Induces IKKβ Degradation Through Chaperone-Mediated Autophagy Via HSPB1 in NCM-Treated Microglia. Front Mol Neurosci. 2018 Mar 15;11:76. [Content Brief]
[3]. Gong J, et al. Ac2-26 ameliorates lung ischemia-reperfusion injury via the eNOS pathway. Biomed Pharmacother. 2019 Sep;117:109194. [Content Brief]
[4]. Luo Z, et al. Annexin-1 Mimetic Peptide Ac2-26 Suppresses Inflammatory Mediators in LPS-Induced Astrocytes and Ameliorates Pain Hypersensitivity in a Rat Model of Inflammatory Pain. Cell Mol Neurobiol. 2020 May;40(4):569-585. [Content Brief]
[5]. Zheng Y, et al. Annexin A1 (Ac2-26)-dependent Fpr2 receptor alleviates sepsis-induced acute kidney injury by inhibiting inflammation and apoptosis in vivo and in vitro. Inflamm Res. 2023 Feb;72(2):347-362. [Content Brief]
[6]. Qin CX, et al. Cardioprotective Actions of the Annexin-A1 N-Terminal Peptide, Ac2-26, Against Myocardial Infarction. Front Pharmacol. 2019 Apr 3;10:269. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ac2-26 TFA Related Classifications
HY-P1098A Related Classifications
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