Fumiquinazoline A
Fumiquinazoline A is a peptidyl quinazolinone indole alkaloid isolated from Aspergillus fumigatus, with antifungal activity. Fumiquinazoline A serves as a substrate for the flavoenzyme Af12070 and FAD-dependent amide oxidase Af12070, which oxidizes it into the seven-membered spiroaminal Fumiquinazoline C. Fumiquinazoline A is applicable to studies related to fungal infections.
For research use only. We do not sell to patients.
- CAS No.: 140715-85-1
- Formula: C24H23N5O4
- Molecular Weight:445.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Fumiquinazoline A serves as a substrate for the FAD-dependent oxidase Af12070 Δ1-24, which drives O2 consumption with an apparent turnover number of 4.6 min-1[1].
Fumiquinazoline A (200 µM; 0.1-20 hrs) is oxidized by Af12070 Δ1-24 to form the seven-membered spiroaminal Fumiquinazoline C[1].
Fumiquinazoline A (compound 2) exhibits moderate antifungal activity against phytopathogenic fungi, with an MIC value of 12.5-25 μg/mL, and its activity is stronger than that of Fumiquinazoline D (HY-125523)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 140715-85-1
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Molecular Weight 445.47
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Formula C24H23N5O4
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SMILES
O[C@@]1([C@]2([H])N(C([C@@H](N2)C)=O)C3=CC=CC=C31)C[C@H]4N5C([C@@H](NC4=O)C)=NC6=CC=CC=C6C5=O
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Structure Classification
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Initial Source
Aspergillus fumigatus
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ames BD, et al. Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. Biochemistry. 2011 Oct 11;50(40):8756-69. [Content Brief]
[2]. An CY, et al. Aniquinazolines A-D, four new quinazolinone alkaloids from marine-derived endophytic fungus Aspergillus nidulans. Marine drugs. 2013 Jul 23;11(7):2682-94. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fumiquinazoline A Related Classifications
HY-N19916 Related Classifications
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