140715-85-1
Chemical Structure
Fumiquinazoline A
- CAS No.: 140715-85-1
- Formula:C24H23N5O4
- Molecular Weight:445.47
InChIKey: DQQCCKFZJNINST-VCPZKGNQSA-N
SMILES: O[C@@]1([C@]2([H])N(C([C@@H](N2)C)=O)C3=CC=CC=C31)C[C@H]4N5C([C@@H](NC4=O)C)=NC6=CC=CC=C6C5=O
Biological Activity: Fumiquinazoline A is a peptidyl quinazolinone indole alkaloid isolated from Aspergillus fumigatus, with antifungal activity. Fumiquinazoline A serves as a substrate for the flavoenzyme Af12070 and FAD-dependent amide oxidase Af12070, which oxidizes it into the seven-membered spiroaminal Fumiquinazoline C. Fumiquinazoline A is applicable to studies related to fungal infections[1][2][3].
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Fumiquinazoline A | Fumiquinazoline A is a peptidyl quinazolinone indole alkaloid isolated from Aspergillus fumigatus, with antifungal activity. Fumiquinazoline A serves as a substrate for the flavoenzyme Af12070 and FAD-dependent amide oxidase Af12070, which oxidizes it into the seven-membered spiroaminal Fumiquinazoline C. Fumiquinazoline A is applicable to studies related to fungal infections. | |||||||||||||||||||||
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- [1]. Ames BD, et al. Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. Biochemistry. 2011 Oct 11;50(40):8756-69. [Content Brief]
- [2]. An CY, et al. Aniquinazolines A-D, four new quinazolinone alkaloids from marine-derived endophytic fungus Aspergillus nidulans. Marine drugs. 2013 Jul 23;11(7):2682-94. [Content Brief]
- [3]. Resende D I S P, et al. Chemistry of the fumiquinazolines and structurally related alkaloids. Natural Product Reports, 2019, 36(1): 7-34.
Keywords
