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Referencia número: HY-N19916

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Fumiquinazoline A

Fumiquinazoline A is a peptidyl quinazolinone indole alkaloid isolated from Aspergillus fumigatus, with antifungal activity. Fumiquinazoline A serves as a substrate for the flavoenzyme Af12070 and FAD-dependent amide oxidase Af12070, which oxidizes it into the seven-membered spiroaminal Fumiquinazoline C. Fumiquinazoline A is applicable to studies related to fungal infections.

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No. CAS: 140715-85-1
Fòrmula: C₂₄H₂₃N₅O₄
Peso molecular:445.47

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Fumiquinazoline A Chemical Structure

No. CAS: 140715-85-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Endogenous Metabolite :

In Vitro

Fungal InfectionOthers

Fungal Infection

Fumiquinazoline A (compound 2) exhibits moderate antifungal activity against phytopathogenic fungi, with an MIC value of 12.5-25 μg/mL, and its activity is stronger than that of Fumiquinazoline D (HY-125523)^[3].

Others

Fumiquinazoline A serves as a substrate for the FAD-dependent oxidase Af12070 Δ1-24, which drives O₂ consumption with an apparent turnover number of 4.6 min^-1^[1].
Fumiquinazoline A (200 µM; 0.1-20 hrs) is oxidized by Af12070 Δ1-24 to form the seven-membered spiroaminal Fumiquinazoline C^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 140715-85-1
Peso molecular 445.47
Fòrmula C₂₄H₂₃N₅O₄
SMILES

O[C@@]1([C@]2([H])N(C([C@@H](N2)C)=O)C3=CC=CC=C31)C[C@H]4N5C([C@@H](NC4=O)C)=NC6=CC=CC=C6C5=O
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
- Microorganism
Aspergillus fumigatus
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Ames BD, et al. Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. Biochemistry. 2011 Oct 11;50(40):8756-69. [Content Brief]

[2]. An CY, et al. Aniquinazolines A-D, four new quinazolinone alkaloids from marine-derived endophytic fungus Aspergillus nidulans. Marine drugs. 2013 Jul 23;11(7):2682-94. [Content Brief]

[3]. Resende D I S P, et al. Chemistry of the fumiquinazolines and structurally related alkaloids. Natural Product Reports, 2019, 36(1): 7-34.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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