Tyrphostin A1
Based on 1 publication(s) in Google Scholar
Tyrphostin A1(AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells.
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- 純度: 98.96%
- CAS 番号: 2826-26-8
- 分子式: C11H8N2O
- 分子量:184.19
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Tyrphostin A1
More
生物活性
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IL-12 |
化学情報
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CAS 番号 2826-26-8
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性状 Solid
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分子量 184.19
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分子式 C11H8N2O
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Color Off-white to yellow
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SMILES
N#C/C(C#N)=C\C1=CC=C(OC)C=C1
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別名
Tyrphostin 1; AG9
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Pflugers Arch
Unlocking the potential: unveiling tyrphostins with Michael-reactive cyanoacrylate motif as promising inhibitors of human 5-lipoxygenase. [Abstract]2024 Dec;476(12):1913-1928. PMID: 39347835
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (542.92 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (273 KB)
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SDS (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Du C, et al. Inhibition of CD40 signaling pathway by tyrphostin A1 reduces secretion of IL-12 in macrophage, Th1 cell development and experimental allergic encephalomyelitis in SJL/J mice. J Neuroimmunol. 2001 Mar 1;114(1-2):69-79. [Content Brief]
[2]. Ogura T, et al. Activation of background membrane conductance by the tyrosine kinase inhibitor tyrphostin A23 and its inactive analog tyrphostin A1 in guinea pig ventricular myocytes. Jpn J Pharmacol. 2001 Nov;87(3):235-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.4292 mL | 27.1459 mL | 54.2918 mL | 135.7294 mL |
| 5 mM | 1.0858 mL | 5.4292 mL | 10.8584 mL | 27.1459 mL | |
| 10 mM | 0.5429 mL | 2.7146 mL | 5.4292 mL | 13.5729 mL | |
| 15 mM | 0.3619 mL | 1.8097 mL | 3.6195 mL | 9.0486 mL | |
| 20 mM | 0.2715 mL | 1.3573 mL | 2.7146 mL | 6.7865 mL | |
| 25 mM | 0.2172 mL | 1.0858 mL | 2.1717 mL | 5.4292 mL | |
| 30 mM | 0.1810 mL | 0.9049 mL | 1.8097 mL | 4.5243 mL | |
| 40 mM | 0.1357 mL | 0.6786 mL | 1.3573 mL | 3.3932 mL | |
| 50 mM | 0.1086 mL | 0.5429 mL | 1.0858 mL | 2.7146 mL | |
| 60 mM | 0.0905 mL | 0.4524 mL | 0.9049 mL | 2.2622 mL | |
| 80 mM | 0.0679 mL | 0.3393 mL | 0.6786 mL | 1.6966 mL | |
| 100 mM | 0.0543 mL | 0.2715 mL | 0.5429 mL | 1.3573 mL |
Tyrphostin A1 関連分類
HY-16668 関連分類
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