Antitumor agent-19
Antitumor agent-19 is an antitumor agent that targets tumor-associated macrophages (TAMs) and can be used as a potent TAMs modulator. Antitumor agent-19 can increase TNF-alpha levels in tumor cells with EC50 values???of 17.18 μM and 18.87 μM in RAW 264.7 cells and BMDM cells, respectively.
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- CAS 番号: 2379727-90-7
- 分子式: C24H21ClF3N5O
- 分子量:487.90
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
tumor-associated macrophages (TAMs)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BMDM | EC50 |
18.87 μM
Compound: 23a
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Increase in TNF-alpha production in mouse BMDM cells incubated for 24 hrs by ELISA
Increase in TNF-alpha production in mouse BMDM cells incubated for 24 hrs by ELISA
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[PMID: 31605873] |
| RAW264.7 | EC50 |
17.18 μM
Compound: 23a
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Increase in TNF-alpha production in mouse RAW264.7 cells incubated for 24 hrs by ELISA
Increase in TNF-alpha production in mouse RAW264.7 cells incubated for 24 hrs by ELISA
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[PMID: 31605873] |
Antitumor agent-19 (Compound 23a; 10-50 μM; 1 hour; RAW 264.7 cells) treatment effectively induces the expression of M1-phenotype macrophage markers (IL-1β, TNF-α, iNOS and IL-12α) in a dose-dependent manner. Antitumor agent-19 is found to dose-dependently repolarize TAMs from M1 (anti-tumor) and M2 (pro-tumor)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7 cells
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Concentration:10 µM, 20 µM, or 50 µM
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Incubation Time:1 hour
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Result:Induced the expression of M1-phenotype macrophage markers (IL-1β, TNF-α, iNOS and IL-12α) in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Six-to eight-week-old C57BL/6 female mice with lewis lung cancer cells (LLC)[1]
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Dosage:5 mg/kg
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Administration:Intraperitoneal injection; every other day; for 30 days
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Result:Remarkably inhibited tumor growth of the LLC mouse model.
化学情報
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CAS 番号 2379727-90-7
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分子量 487.90
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分子式 C24H21ClF3N5O
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SMILES
O=C(NC1CCC(NC2=C3C(C4=CN(C)N=C4)=CC=C2)=C3C1)NC5=CC=C(Cl)C(C(F)(F)F)=C5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antitumor agent-19 関連分類
HY-128776 関連分類
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