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製品番号: HY-100714D

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DL-AP5 lithium

(別名: 2-APV lithium; DL-2-Amino-5-phosphonovaleric acid lithium)

3 Cited Publications

カスタマーレビュー

Based on 3 publication(s) in Google Scholar

DL-AP5 (2-APV) lithium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 lithium shows significantly antinociceptive activity. DL-AP5 lithium specifically blocks on channels in the rabbit retina.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 125229-62-1
分子式: C₅H₁₁LiNO₅P
分子量:203.06

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

DL-AP5 lithium 構造式

CAS 番号: 125229-62-1

容量

価格（税別）

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Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
Publications (3)
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

NMDA Receptor

iGluR アイソフォーム固有の製品をすべて表示 :

体外実験

DL-AP5 (100 μM) partially prevents glutamate-induced increase in Arc/Arg3.1 protein levels^[5].
DL-AP5 decreases the NMDA-induced Arc/Arg3.1 upregulation^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

DL-AP5 (0-10 μg/rat, Intra-CA1) significantly decreases the effect of NMDA^[3].
DL-AP5 (0-10 nmol, Intracerebroventricular injection) causes a dose-dependent increase in food consumption^[4].
DL-AP5 (5 nmol, Intracerebroventricular injection) attenuates the decreased food consumption induced by the intracerebroventricular injection of ghrelin^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Wistar rats (180-230 g)^[3]
Dosage:

1, 3.2 and 10 μg/rat
Administration:

Injected into the intra-dorsal hippocampal (intra-CA1) immediately after shock administration, once
Result:

Significantly decreased the effect of NMDA (10^-2 μg/rat, intra-CA1) with significant interaction.

Animal Model:

Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)^[4]
Dosage:

0, 2.5, 5, and 10 nmol; in a volume of 10 μL
Administration:

Intracerebroventricular injection
Result:

Caused a dose-dependent increase in food consumption which was significant for 5 and 10 nmol doses.

Animal Model:

Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)^[4]
Dosage:

5 nmol
Administration:

Intracerebroventricular injection, followed by ghrelin (0.6 nmol)
Result:

Attenuated the decreased food consumption induced by the intracerebroventricular injection of ghrelin.

化学情報

CAS 番号 125229-62-1
分子量 203.06
分子式 C₅H₁₁LiNO₅P
SMILES

NC(CCCP(O)(O)=O)C(O[Li])=O
別名

2-APV lithium; DL-2-Amino-5-phosphonovaleric acid lithium
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

All In Vivo Efficacy StudyBio/Physico-chemical Assay

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Journal Impact Factor

Neuron

Dual anterior insula-prefrontal cortex circuits mediate chronic stress-induced social interaction deficits. [Abstract]

2026 Mar 26:S0896-6273(26)00120-0. PMID: 41895265
Int J Biol Macromol

SETD2 deficiency in peripheral sensory neurons induces allodynia by promoting NMDA receptor expression through NFAT5 in rodent models. [Abstract]

2024 Oct 28:136767. PMID: 39476923

DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2024 Oct 28:136767. [Abstract]

Effects of a single injection of DL-AP5 (5 μg; i.t.) on the tactile and pressure withdrawal thresholds and heat withdrawal latency within 2 h in KD-Setd2 and NC rats.

DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2024 Oct 28:136767. [Abstract]

The mean changes of baseline values and the DL-AP5 (50 μM) effect on the frequency and amplitude of mEPSCs in spinal dorsal horn neurons of Setd2^fl/fl and Setd2-cKO mice.
bioRxiv

2025 July 07.

DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.

DL-AP5 (50 μM) abolished the training effect so that trained and untrained trajectories overlapped in the CNS-3D organoids.

DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.

DL-AP5 (50 μM) suppressed activity-dependent neuronal recruitment and blocked stimulation-driven LTP in CNS-3D organoid networks, as the number of unique neurons remained low under NMDA receptor blockade.

DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.

DL-AP5 (200 μM). Heat map of GSVA scores across 15 GO terms associated with learning, memory, LTP, and synaptic plasticity.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Murray CW, et al. Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model. Pain. 1991;44(2):179-185. [Content Brief]

[2]. Massey SC, et al. N-methyl-D-aspartate receptors of ganglion cells in rabbit retina. J Neurophysiol. 1990;63(1):16-30. [Content Brief]

[3]. Jafari-Sabet M. NMDA receptor blockers prevents the facilitatory effects of post-training intra-dorsal hippocampal NMDA and physostigmine on memory retention of passive avoidance learning in rats. Behav Brain Res. 2006 Apr 25;169(1):120-7. [Content Brief]

[4]. Taati M, et al. The effects of DL-AP5 and glutamate on ghrelin-induced feeding behavior in 3-h food-deprived broiler cockerels. J Physiol Biochem. 2011 Jun;67(2):217-23. [Content Brief]

[5]. Chen T, et al. Glutamate-induced rapid induction of Arc/Arg3.1 requires NMDA receptor-mediated phosphorylation of ERK and CREB. Neurosci Lett. 2017 Nov 20;661:23-28. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

DL-AP5 lithium

3 Cited Publications

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
Publications (3)
純度とドキュメンテーション
参考文献

1/16
1/16

DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.

Customer Validation
DL-AP5 (50 μM) abolished the training effect so that trained and untrained trajectories overlapped in the CNS-3D organoids.
1/16

DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.

Customer Validation
DL-AP5 (50 μM) suppressed activity-dependent neuronal recruitment and blocked stimulation-driven LTP in CNS-3D organoid networks, as the number of unique neurons remained low under NMDA receptor blockade.
1/16

DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 July 07.

Customer Validation
DL-AP5 (200 μM). Heat map of GSVA scores across 15 GO terms associated with learning, memory, LTP, and synaptic plasticity.
1/16

DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2024 Oct 28:136767. [Abstract]

Customer Validation
Effects of a single injection of DL-AP5 (5 μg; i.t.) on the tactile and pressure withdrawal thresholds and heat withdrawal latency within 2 h in KD-Setd2 and NC rats.
1/16

DL-AP5 lithium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2024 Oct 28:136767. [Abstract]

Customer Validation
The mean changes of baseline values and the DL-AP5 (50 μM) effect on the frequency and amplitude of mEPSCs in spinal dorsal horn neurons of Setd2^fl/fl and Setd2-cKO mice.

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DL-AP5 lithium

MedChemExpress（MCE）の使用を引用している文献 DL-AP5 lithium

iGluR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (3)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

DL-AP5 lithium 関連分類

HY-100714D 関連分類