(E)-C-HDMAPP ammonium
(E)-C-HDMAPP ammonium, is a potent phosphoantigen in ammonium form as well as a pyrophosphonate form of (E)-HDMAPP. (E)-C-HDMAPP is also an effective activator of γδ-T cells, induces T-cell stimulatory responses in vitro (EC50=0.91 nM for TNF-α release).
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- CAS 番号: 933030-60-5
- 分子式: C6H23N3O7P2
- 分子量:311.21
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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TNFRSF1A |
(E)-C-HDMAPP (compound 5E) (2 μM) increases the release of TNF-α in primary polyclonal human Vγ9Vδ2 T-cell with stimulating bioactivity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nonhuman Primate Model in Cynomolgus[1]
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Dosage:0.02 mg/kg, 0.1 mg/kg, 0.5 mg/kg, 2.5 mg/kg, 5 mg/kg, and 10 mg/kg
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Administration:Intravenous injection; once with daily s.c. low doses IL-2 to sustain γδ-T-cell proliferation, for 15 days
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Result:Significantly increased γδ-cells in vivo at 0.02 mg/kg. Reached maximal effect at 5 mg/kg and 10 mg/kg.
化学情報
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CAS 番号 933030-60-5
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分子量 311.21
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分子式 C6H23N3O7P2
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SMILES
OC/C(C)=C/CCP(OP(O)(O)=O)(O)=O.N.N.N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
(E)-C-HDMAPP ammonium 関連分類
HY-134950 関連分類
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