Estradiol 3-glucuronide
Based on 1 publication(s) in Google Scholar
Estradiol 3-glucuronide is an estrogen metabolite, which is a glucuronide conjugate formed from Estradiol (HY-B0141) via catalysis by uridine diphosphate glucuronosyltransferases in tissues such as the liver. Estradiol 3-glucuronide is a potent substrate of Mrp2, with an S50 value of 55.7 μM. Estradiol 3-glucuronide achieves hepatobiliary transport in hepatocytes through basolateral uptake via OATP1B1, OATP1B3 and OATP2B1, as well as apical efflux via MRP2 and BCRP.
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- 純度: 97.62%
- CAS 番号: 15270-30-1
- 分子式: C24H32O8
- 分子量:448.51
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保管条件:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Estradiol 3-glucuronide
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
120 μM
Compound: Estradiol 3-glucuronide
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TP_TRANSPORTER: inhibition of E217betaG uptake in membrane vesicles from MRP4-expressing Sf9 cells
TP_TRANSPORTER: inhibition of E217betaG uptake in membrane vesicles from MRP4-expressing Sf9 cells
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[PMID: 12523936] |
| Sf9 | IC50 |
80 μM
Compound: Estradiol 3-glucuronide
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TP_TRANSPORTER: inhibition of DHEAS in membrane vesicles from MRP4-expressing Sf9 cells
TP_TRANSPORTER: inhibition of DHEAS in membrane vesicles from MRP4-expressing Sf9 cells
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[PMID: 12523936] |
Estradiol 3-glucuronide (1-5 μM; 2 minutes) is a substrate for OATP1B1, OATP1B3, and OATP2B1 in transfected HEK293T cells, with OATP2B1 exhibiting the highest transport efficiency (Vmax/Km = 33.2) and acting as the primary transporter at low concentrations[2].
Estradiol 3-glucuronide (5 μM; 2 minutes) uptake by OATP1B1, OATP1B3, and OATP2B1 in transfected HEK293T cells is differentially inhibited by known OATP substrates/inhibitors, with estrone-3-sulfate showing the strongest inhibitory effect on OATP1B1-mediated uptake (IC50 = 0.05 μM)[2].
Estradiol 3-glucuronide (50 μM; 2 minutes) weakly to moderately inhibits OATP1B3-, OATP2B1-mediated estrone-3-sulfate uptake and OATP1B1-, OATP1B3-, OATP2B1-mediated Rosuvastatin (HY-17504A) uptake in transfected HEK293T cells[2].
Estradiol 3-glucuronide (30-110 nM; up to 20 min) is a substrate of rat Mrp2 expressed in Sf9 cell membrane vesicles, with an S50 of 55.7 μM and slight negative cooperativity in transport[1].
Estradiol 3-glucuronide (0.4-400 μM) competitively and completely inhibits rat Mrp2-mediated transport of Estradiol 17-glucuronide in Sf9 cell membrane vesicles with an IC50 of 14.2 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 15270-30-1
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性状 Solid
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分子量 448.51
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分子式 C24H32O8
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Color White to off-white
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SMILES
C[C@@]12[C@](CC[C@@H]2O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)C(O)=O)C=C4CC3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
H2O : 1 mg/mL (2.23 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (394 KB)
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- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Gerk PM, et al. Estradiol 3-glucuronide is transported by the multidrug resistance-associated protein 2 but does not activate the allosteric site bound by estradiol 17-glucuronide. Drug Metab Dispos. 2004;32(10):1139-1145. [Content Brief]
[2].
Li L, et al. Hepatic uptake of estradiol-3-glucuronide and estradiol-3-sulfate-17β-glucuronide by human organic anion transporting polypeptides 1B1, 1B3, and 2B1. Drug Metab Dispos. 2025 Sep;53(9):100132.
[Content Brief]
[3].
Nambara T, et al. A direct radioimmunoassay of estradiol 3-glucuronide using specific antiserum. Chem Pharm Bull (Tokyo). 1983 Oct;31(10):3583-8.
[Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.2296 mL | 11.1480 mL | 22.2960 mL | 55.7401 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Estradiol 3-glucuronide 関連分類
HY-W585842 関連分類
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