Folate-MS432
Folate-MS432, a PROTAC, is capable of degrading MEKs in a folate receptor-dependent manner in cancer cells.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2769735-56-8
- 分子式: C77H94F3IN18O12S
- 分子量:1679.65
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
PROTACs アイソフォーム固有の製品をすべて表示
More
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | IC50 |
246 nM
Compound: 36
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Antiproliferative activity against human HT-29 cells
Antiproliferative activity against human HT-29 cells
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[PMID: 35763424] |
| HT-29 | IC50 |
436 nM
Compound: 10; FA-MS432
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Anticancer activity against human HT-29 cells assessed as cell growth inhibition
Anticancer activity against human HT-29 cells assessed as cell growth inhibition
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[PMID: 37317568] |
| HT-29 | IC50 |
436 nM
Compound: 62
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Antiproliferative activity against human HT-29 cells
Antiproliferative activity against human HT-29 cells
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[PMID: 34656901] |
| SK-MEL-28 | IC50 |
390 nM
Compound: 62
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Antiproliferative activity against human SK-MEL-28 cells
Antiproliferative activity against human SK-MEL-28 cells
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[PMID: 34656901] |
化学情報
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CAS 番号 2769735-56-8
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分子量 1679.65
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分子式 C77H94F3IN18O12S
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SMILES
O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCCCCCCCNCCCONC(C2=CC=C(F)C(F)=C2NC3=CC=C(I)C=C3F)=O)=O)=O)C[C@H](OC(CCCCN4C=C(CNC(CC[C@H](NC(C5=CC=C(C=C5)NCC6=CN=C7NC(N)=NC(C7=N6)=O)=O)C(O)=O)=O)N=N4)=O)C1)N[C@H](C8=CC=C(C9=C(C)N=CS9)C=C8)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Folate-MS432 関連分類
HY-115873 関連分類
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