2769735-56-8
Chemical Structure
Folate-MS432
- CAS. Nr.: 2769735-56-8
- Formula:C77H94F3IN18O12S
- Molecular Weight:1679.65
IUPAC Name: N2-(4-(((2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl)amino)benzoyl)-N5-((1-(5-(((3R,5S)-1-((S)-2-(11-((3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)propyl)amino)undecanamido)-3,3-dimethylbutanoyl)-5-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-3-yl)oxy)-5-oxopentyl)-1H-1,2,3-triazol-4-yl)methyl)-L-glutamine
InChIKey: XPXBOJCDLYUMCO-WXWGOGOJSA-N
SMILES: O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCCCCCCCNCCCONC(C2=CC=C(F)C(F)=C2NC3=CC=C(I)C=C3F)=O)=O)=O)C[C@H](OC(CCCCN4C=C(CNC(CC[C@H](NC(C5=CC=C(C=C5)NCC6=CN=C7NC(N)=NC(C7=N6)=O)=O)C(O)=O)=O)N=N4)=O)C1)N[C@H](C8=CC=C(C9=C(C)N=CS9)C=C8)C
Biological Activity: Folate-MS432, a PROTAC, is capable of degrading MEKs in a folate receptor-dependent manner in cancer cells.
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Folate-MS432 | Folate-MS432, a PROTAC, is capable of degrading MEKs in a folate receptor-dependent manner in cancer cells. | |||||||||||||||||||||
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Keywords
