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Cat. No.: HY-115873

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Folate-MS432

Folate-MS432, a PROTAC, is capable of degrading MEKs in a folate receptor-dependent manner in cancer cells.

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CAS No.: 2769735-56-8
Formule: C₇₇H₉₄F₃IN₁₈O₁₂S
Masse moléculaire:1679.65

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Folate-MS432 Chemical Structure

CAS No.: 2769735-56-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Folate-MS432, a PROTAC, is capable of degrading MEKs in a folate receptor-dependent manner in cancer cells.

Voir tous les produits spécifiques à Isoform PROTACs :

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	IC₅₀	246 nM Compound: 36	Antiproliferative activity against human HT-29 cells Antiproliferative activity against human HT-29 cells	[PMID: 35763424]
HT-29	IC₅₀	436 nM Compound: 10; FA-MS432	Anticancer activity against human HT-29 cells assessed as cell growth inhibition Anticancer activity against human HT-29 cells assessed as cell growth inhibition	[PMID: 37317568]
HT-29	IC₅₀	436 nM Compound: 62	Antiproliferative activity against human HT-29 cells Antiproliferative activity against human HT-29 cells	[PMID: 34656901]
SK-MEL-28	IC₅₀	390 nM Compound: 62	Antiproliferative activity against human SK-MEL-28 cells Antiproliferative activity against human SK-MEL-28 cells	[PMID: 34656901]

Chemical Information

CAS No. 2769735-56-8
Masse moléculaire 1679.65
Formule C₇₇H₉₄F₃IN₁₈O₁₂S
SMILES

O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCCCCCCCNCCCONC(C2=CC=C(F)C(F)=C2NC3=CC=C(I)C=C3F)=O)=O)=O)C[C@H](OC(CCCCN4C=C(CNC(CC[C@H](NC(C5=CC=C(C=C5)NCC6=CN=C7NC(N)=NC(C7=N6)=O)=O)C(O)=O)=O)N=N4)=O)C1)N[C@H](C8=CC=C(C9=C(C)N=CS9)C=C8)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Liu J, et al. Cancer Selective Target Degradation by Folate-Caged PROTACs. J Am Chem Soc. 2021 May 19;143(19):7380-7387. [Content Brief]

Calculators

Calculateur de molarité

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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Folate-MS432

Voir tous les produits spécifiques à Isoform PROTACs

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Folate-MS432 Related Classifications

HY-115873 Related Classifications