Imetit dihydrobromide
Based on 1 Customer Validation
Imetit dihydrobromide (VUF 8325 dihydrobromide) is a high affinity and potent agonist of histamine H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. Imetit mimics histamine effect in triggering a shape change in eosinophils (EC50=25 nM).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.16
- CAS 番号: 32385-58-3
- 分子式: C6H12Br2N4S
- 分子量:332.06
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Histamine Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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H3 Receptor 0.3 nM (Ki) |
H4 receptor 2.7 nM (Ki) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats[4]
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Dosage:2.5, 5, 10 mg/kg
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Administration:i.p. (30 min before Apomorphine)
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Result:Reduced the licking response induced by Apomorphine.
化学情報
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CAS 番号 32385-58-3
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性状 Solid
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分子量 332.06
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分子式 C6H12Br2N4S
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Color White to light brown
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SMILES
NC(SCCC1=CN=CN1)=N.Br.Br
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別名
VUF 8325 dihydrobromide; SKF 91105 dihydrobromide
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
H2O : 50 mg/mL (150.58 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Liu C, et al. Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6. [Content Brief]
[2]. Ling P, et al. Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br J Pharmacol. 2004 May;142(1):161-71. [Content Brief]
[3]. Garbarg M, et al. S-[2-(4-imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist. J Pharmacol Exp Ther. 1992 Oct;263(1):304-10. [Content Brief]
[4]. Farzin D, et al. Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rat. Eur J Pharmacol. 2000 Sep 15;404(1-2):169-74. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.0115 mL | 15.0575 mL | 30.1150 mL | 75.2876 mL |
| 5 mM | 0.6023 mL | 3.0115 mL | 6.0230 mL | 15.0575 mL | |
| 10 mM | 0.3012 mL | 1.5058 mL | 3.0115 mL | 7.5288 mL | |
| 15 mM | 0.2008 mL | 1.0038 mL | 2.0077 mL | 5.0192 mL | |
| 20 mM | 0.1506 mL | 0.7529 mL | 1.5058 mL | 3.7644 mL | |
| 25 mM | 0.1205 mL | 0.6023 mL | 1.2046 mL | 3.0115 mL | |
| 30 mM | 0.1004 mL | 0.5019 mL | 1.0038 mL | 2.5096 mL | |
| 40 mM | 0.0753 mL | 0.3764 mL | 0.7529 mL | 1.8822 mL | |
| 50 mM | 0.0602 mL | 0.3012 mL | 0.6023 mL | 1.5058 mL | |
| 60 mM | 0.0502 mL | 0.2510 mL | 0.5019 mL | 1.2548 mL | |
| 80 mM | 0.0376 mL | 0.1882 mL | 0.3764 mL | 0.9411 mL | |
| 100 mM | 0.0301 mL | 0.1506 mL | 0.3012 mL | 0.7529 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Imetit dihydrobromide 関連分類
HY-101173 関連分類
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