KRAS-IN-56
KRAS-IN-56 (Compound 18) is a KRAS inhibitor with an EC50 of 33 μM. KRAS-IN-56 inhibits the interaction between GTP-KRAS and SOS1. KRAS-IN-56 induces a decrease in p-ERK levels. KRAS-IN-56 can be used in research related to lung cancer.
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- CAS 番号: 2375482-34-9
- 分子式: C19H19N3O2
- 分子量:321.37
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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K-RAS 33 μM (EC50) |
KRAS-IN-56 binds to the purified GCP-KRASG12D protein, with a measured Kd value of 20 μM via ITC[1].
KRAS-IN-56 inhibits the interaction between GTP-KRAS and SOS1 in a biochemical assay, with an EC50 of 33 μM[1].
KRAS-IN-56 (10-8-10-4 M; 2 h) induces a dose-dependent decrease in pERK levels in NCI-H358 KRASG12C mutant lung cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2375482-34-9
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分子量 321.37
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分子式 C19H19N3O2
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SMILES
CN(C)CC1=C([C@@H]2C3=CC(O)=CC=C3C(N2)=O)C4=CC=CC=C4N1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
KRAS-IN-56 関連分類
HY-182411 関連分類
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