MG-101 (GMP) (Calpain inhibitor I (GMP)) is MG-101 (HY-18964) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MG-101 (ALLN) is an inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with Kis of 190, 220, 150 and 500 pM, respectively. MG-101 induces apoptosis and inhibits tumor growth, it can be used for the research of colon cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 110044-82-1
- 分子式: C20H37N3O4
- 分子量:383.53
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
MG-101 (GMP) (0-26 μM; 24 h) affects the growth of colon cancer HCT116 cells[1]. MG-101 (GMP) (0-26 μM; 24 h) induces apoptosis of various cancer cells[1]. MG-101 (GMP) (0-26 μM; 24 h) induces Bax-dependent apoptosis in HCT116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HCT116 cell line
-
Concentration:0-26 μM
-
Incubation Time:24 hours
-
Result:Anchorage-independently and significantly decreased the viability of HCT116 cells.
-
Cell Line:HCT116, RKO, SW480 and HepG2 cell lines
-
Concentration:0-26 μM
-
Incubation Time:24 hours
-
Result:Dose-dependently decreased the concentration of pro-caspase 3 and increased the concentration of cleaved-PARP in HCT116 cells. Induced apoptosis of HCT116, RKO, SW480 and HepG2 cells.
-
Cell Line:HCT116, HCT116/p53-/- and HCT116/Bax-/- cell lines
-
Concentration:0-26 μM
-
Incubation Time:24 hours
-
Result:Induced apoptosis via a Bax-dependent manner, but not via a p53-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Female athymic nude mice with HCT116 cells injection[1]
-
Dosage:10 mg/kg
-
Administration:Intraperitoneal injection; 10 mg/kg once daily; for 15 days
-
Result:Significantly decreased tumor weight and volume of treated mice at day 26 compared to control mice, and showed no effect on body weights.
化学情報
-
CAS 番号 110044-82-1
-
分子量 383.53
-
分子式 C20H37N3O4
-
SMILES
O=C(N[C@H](C=O)CCCC)[C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC(C)C
-
別名
Calpain inhibitor I (GMP); Ac-LLnL-CHO (GMP); ALLN (GMP)
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MG-101 (GMP) 関連分類
HY-18964G 関連分類
Powered by Bioz