MNK1/2-IN-6
MNK1/2-IN-6 is a potent and selective MNK1/2 inhibitor with IC50s of 2.3 nM and 3.4 nM for MNK1 and MNK2, respectively. MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner.
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- CAS 番号: 2771087-94-4
- 分子式: C27H24N6O
- 分子量:448.52
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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MNK1 2.3 nM (IC50) |
MNK2 3.4 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DOHH-2 | IC50 |
0.4092 μM
Compound: II-5
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Antiproliferative activity against human DOHH-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human DOHH-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 33971490] |
| TMD8 | IC50 |
0.3896 μM
Compound: II-5
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Antiproliferative activity against human TMD8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human TMD8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 33971490] |
MNK1/2-IN-6 (compound II-5) (72 h) shows antiproliferative activity with IC50s of 0.3896µM, 0.4092 µM for TMD-8, DOHH-2 cells, respectively[1].
MNK1/2-IN-6 (0.25, 0.5, 1 µM; 24 h) induces TMD-8 cells apoptosis in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:TMD-8, DOHH-2 cells
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Concentration:
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Incubation Time:72 h
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Result:Showed antiproliferative activity with IC50s of 0.39µM, 0.41 µM for TMD-8, DOHH-2 cells, respectively.
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Cell Line:TMD-8 cells
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Concentration:0.25, 0.5, 1 µM
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Incubation Time:24 h
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Result:Induced TMD-8 cells apoptosis in a concentration-dependent manner.
化学情報
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CAS 番号 2771087-94-4
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分子量 448.52
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分子式 C27H24N6O
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SMILES
N[C@H]1CCCN(C1)C(C2=CC=C(C=C2)C3=NN4C(C5=CC=C6C=NC=CC6=C5)=CN=C4C=C3)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MNK1/2-IN-6 関連分類
HY-146735 関連分類
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