NSC-88915
NSC-88915 is an inhibitor of Tdp1 with an IC50 of 7.7 μM. NSC-88915 is a C21-subsitited progesterone derivative.
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- CAS 番号: 21170-34-3
- 分子式: C27H33BrO5S
- 分子量:549.52
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
化学情報
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CAS 番号 21170-34-3
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分子量 549.52
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分子式 C27H33BrO5S
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SMILES
O=S(C1=CC=C(C=C1)Br)(OCC([C@H]2CC[C@]3([C@@]4(CCC5=CC(CC[C@@]5([C@]4(CC[C@]23C)[H])C)=O)[H])[H])=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Dexheimer, T. S., et al., (2009). 4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors. Journal of medicinal chemistry, 52(22), 7122-7131. [Content Brief]
[2]. Nguyen, T. X., et al., (2012). Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors. Journal of medicinal chemistry, 55(9), 4457-4478. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NSC-88915 関連分類
HY-124486 関連分類
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