NSC243928 mesylate
Based on 1 publication(s) in Google Scholar
NSC243928 mesylate is a human lymphocyte antigen 6 (LY6) binder, which also acts as an inhibitor of cell growth and has anticancer activity.
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- 純度: 99.33%
- CAS 番号: 59988-01-1
- 分子式: C23H25N3O6S2
- 分子量:503.59
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 NSC243928 mesylate
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生物活性
NSC243928 mesylate (2 μM, 24 h) induced cell death in MDA-MB-231 control cells and showed an increase in cell viability in LY6K knockdown cells, thus suggesting that NSC243928 may induce cell death through the LY6K pathway[1].
NSC243928 mesylate inhibits MDA-MB-231, Hs-578-T, BT-549 and OVCAR-8 cells with the IC50 values of 5.683 μM, 7.309 μM, 7.954 μM and 4.167 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 59988-01-1
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性状 Solid
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分子量 503.59
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分子式 C23H25N3O6S2
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Color Light yellow to yellow
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SMILES
O=S(O)(C)=O.O=S(NC1=CC=C(C(OC)=C1)NC2=C3C=CC=CC3=NC4=C2C=CC=C4)(CC)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
Targeting the LY6H-PI3K/AKT autophagy axis suppresses HCC malignancy and reveals a druggable vulnerability. [Abstract]2026 Jun 15. PMID: 42297773
溶剤 & 溶解度
DMSO : 10 mg/mL (19.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9857 mL | 9.9287 mL | 19.8574 mL | 49.6436 mL |
| 5 mM | 0.3971 mL | 1.9857 mL | 3.9715 mL | 9.9287 mL | |
| 10 mM | 0.1986 mL | 0.9929 mL | 1.9857 mL | 4.9644 mL | |
| 15 mM | 0.1324 mL | 0.6619 mL | 1.3238 mL | 3.3096 mL |
NSC243928 mesylate 関連分類
HY-123885 関連分類
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