(R)-PVTX-405
(R)-PVTX-405 is a IKZF2 molecular glue degrader with a DC50 of 4.1 nM. (R)-PVTX-405 is the (R)-enantiomer of PVTX-405 (HY-172930). PVTX-405 is an orally active IKZF2 molecular glue degrader that significantly inhibits MC38 tumor growth in mouse tumor xenograft models. (R)-PVTX-405 can be used in cancer-related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2991023-13-1
- 分子式: C30H31N5O4
- 分子量:525.60
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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IKZF2 4.1 nM (DC50) |
(R)-PVTX-405 (0.017 nM-10 μM; 6 h) induces IKZF2 degradation in HEK293 IKZF2 HiBiT cells, with a DC50 of 4.1 nM and a maximum degradation rate of 89%[1].
(R)-PVTX-405 is the (R)-enantiomer of PVTX-405 (HY-172930) (compound 16a). PVTX-405 is a selective oral IKZF2 molecular glue degrader with a DC50 of 0.7 nM and a Dmax of 91%. PVTX-405 improves degradation efficiency, significantly reduces off-target degradation, and attenuates hERG inhibition with an IC50 of 48 µM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2991023-13-1
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性状 Solid
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分子量 525.60
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分子式 C30H31N5O4
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SMILES
O=C1N(CC2=C1C=CC3=C2OCC34CCN(CC5=CC=CC(C(C=N6)=CN6C)=C5)CC4)[C@@H](C7=O)CCC(N7)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
(R)-PVTX-405 関連分類
HY-172930B 関連分類
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