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製品番号: HY-145454B

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(Rac)-Preclamol

(別名: (±)-3-PPP)

(Rac)-Preclamol ((±)-3-PPP) is the racemate of (R)-Preclamol (HY-145454A) and Preclamol (HY-145454A). (Rac)-Preclamol exhibits autoreceptor agonistic activity at dopamine Dopamine Receptor, with almost no effect on postsynaptic dopamine receptors. (Rac)-Preclamol inhibits spontaneous motor activity and the γ-butyrolactone-induced increase in mature striatal Tyrosine Hydroxylase activity. (Rac)-Preclamol can be used in research related to neurological diseases.

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CAS 番号: 75240-91-4
分子式: C₁₄H₂₁NO
分子量:219.33

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

(Rac)-Preclamol 構造式

CAS 番号: 75240-91-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Dopamine Receptor アイソフォーム固有の製品をすべて表示 :

体内実験

(Rac)-Preclamol ((±)-3-PPP) (0.1-10 mg/kg; s.c.; single dose; 45 minutes prior to sacrifice (biochemical experiments)) dose-dependently reduces spontaneous locomotor activity and inhibits GBL-induced striatal DOPA accumulation in 28-day-old rats, with no significant effects on locomotion or striatal DOPA accumulation in rats younger than 14 days old^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (ages 1, 4, 7, 14, and 28 days)^[1]
Dosage:

0.1 mg/kg; 1 mg/kg; 10 mg/kg; 10 mg/kg
Administration:

s.c.; single dose; 45 minutes prior to sacrifice
Result:

Reduced 28-day-old rats’ spontaneous locomotor activity in a 0.1-10 mg/kg dose-dependent manner and cut activity to ~30% of control at 10 mg/kg, while exerted no locomotor effects on 1/4/7/14-day-old rats.
Lowered GBL-induced striatal DOPA accumulation from 1618 ng/g to 1127 ng/g in 28-day-old rats at 10 mg/kg and caused only trivial non-significant reduction in 4-day-old rats, without changing striatal and whole-brain DA, NA, DOPAC levels in either age group.

化学情報

CAS 番号 75240-91-4
分子量 219.33
分子式 C₁₄H₂₁NO
SMILES

OC1=CC=CC(=C1)C2CN(CCC)CCC2
別名

(±)-3-PPP
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Hedner T, et al. Development of dopamine autoreceptors in the postnatal rat brain. Journal of neural transmission. 1985;62(1-2):53-63. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

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生物活性
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(Rac)-Preclamol

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