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製品番号: HY-139104

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Thailanstatin D

Thailanstatin D, an analogue of Thailanstatin A, is able to inhibit AR-V7 gene splicing by interfering the interaction between U2AF65 and SAP155 and preventing them from binding to polypyrimidine tract located between the branch point and the 3' splice site. Thailanstatin D exhibits a potent tumor inhibitory effect on human CRPC xenografts leading to cell apoptosis.

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CAS 番号: 1609105-89-6
分子式: C₂₈H₄₁NO₈
分子量:519.63

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Thailanstatin D 構造式

CAS 番号: 1609105-89-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
BT-474	IC₅₀	4.8 nM Compound: 4	Cytotoxicity against human BT474 cells after 4 days by MTS/cell proliferation assay Cytotoxicity against human BT474 cells after 4 days by MTS/cell proliferation assay	[PMID: 25098528]
MDA-MB-468	IC₅₀	3.4 nM Compound: 4	Cytotoxicity against human MDA-MB-468 cells after 4 days by MTS/cell proliferation assay Cytotoxicity against human MDA-MB-468 cells after 4 days by MTS/cell proliferation assay	[PMID: 25098528]
NCI-H1975	IC₅₀	3.6 nM Compound: 4	Cytotoxicity against human NCI-H1975 cells after 4 days by MTS/cell proliferation assay Cytotoxicity against human NCI-H1975 cells after 4 days by MTS/cell proliferation assay	[PMID: 25098528]
NCI-N87	IC₅₀	2 nM Compound: 4	Cytotoxicity against human NCI-N87 cells after 4 days by MTS/cell proliferation assay Cytotoxicity against human NCI-N87 cells after 4 days by MTS/cell proliferation assay	[PMID: 25098528]

体外実験

Thailanstatin D (0-50 nM; 4 hours) significantly decreases the protein levels of AR-V7 and other AR-Vs (AR splice variants)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

VCaP, 22RV1 and LN95 cells
Concentration:

0-50 nM
Incubation Time:

4 hours
Result:

The mRNA levels of both AR-V7 and AR-FL were suppressed by Thailanstatin D in a dose-dependent manner.

体内実験

Thailanstatin D (300 µg/kg; ALZET osmotic pumps; daily for 4 days) significantly inhibits the tumor growth^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NOD-SCID mice ( Mice bearing 22RV1 xenografts)^[1]
Dosage:

300 µg/kg
Administration:

ALZET osmotic pumps; daily for 4 days
Result:

Significantly inhibited the tumor growth.

化学情報

CAS 番号 1609105-89-6
分子量 519.63
分子式 C₂₈H₄₁NO₈
SMILES

C[C@@H](C[C@H]([C@H](O1)C)NC(/C=C\[C@H](C)OC(C)=O)=O)[C@@H]1C/C=C(C)/C=C/[C@@H]2C[C@@]3(C[C@H](O2)CC(O)=O)CO3
Structure Classification
- Alkaloids
Initial Source
- Microorganisms
Burkholderia thailandensis
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wang B, et al. Developing new targeting strategy for androgen receptor variants in castration resistant prostate cancer. Int J Cancer. 2017;141(10):2121-2130. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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希釈計算機

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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Thailanstatin D

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Thailanstatin D 関連分類

HY-139104 関連分類