2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. JT002

JT002 is an orally active inhibitor of the NLRP3 inflammasome. JT002 reduces NLRP3-dependent proinflammatory cytokine (such as IL-1β, IL-1α, IL-18) production and pyroptosis. JT002 blocks NLRP3 inflammasome complex formation. JT002 reduces airway hyperresponsiveness and airway neutrophilia in mice.

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JT002 Chemical Structure

JT002 Chemical Structure

CAS No. : 2238820-43-2

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JT002 Related Antibodies

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Description

JT002 is an orally active inhibitor of the NLRP3 inflammasome. JT002 reduces NLRP3-dependent proinflammatory cytokine (such as IL-1β, IL-1α, IL-18) production and pyroptosis. JT002 blocks NLRP3 inflammasome complex formation. JT002 reduces airway hyperresponsiveness and airway neutrophilia in mice[1].

Molecular Weight

432.49

Formula

C20H24N4O5S
CAS No.
SMILES

O=C(NS(=O)(C1=C(OC[C@@H](OC)C2)N2N=C1)=O)NC3=C(CCC4)C4=CC5=C3CCC5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JT002 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JT0022238820-43-2JT 002JT-002NOD-like Receptor (NLR)inflammationairway hyperresponsivenessneutrophiliaIL-1βIL-1αIL-18NLRP3 inflammasomeInhibitorinhibitorinhibit

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