2238820-43-2
2238820-43-2
Chemical Structure
JT002
- CAS No.: 2238820-43-2
- Formula:C20H24N4O5S
- Molecular Weight:432.49
InChIKey: CNMWUSIUEKOFMW-AWEZNQCLSA-N
SMILES: O=C(NS(=O)(C1=C(OC[C@@H](OC)C2)N2N=C1)=O)NC3=C(CCC4)C4=CC5=C3CCC5
Biological Activity: JT002 is an orally active and selective NLRP3 inflammasome assembly inhibitor. JT002 reduces NLRP3-dependent proinflammatory cytokine (such as IL-1β, IL-1α, IL-18) production and pyroptosis. JT002 blocks NLRP3 inflammasome complex formation. JT002 reduces airway hyperresponsiveness and airway neutrophilia in mice. JT002 can be used for the study of a variety of inflammatory diseases, such as Muckle-Wells syndrome (MWS)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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JT002 | 99.54% | JT002 is an orally active and selective NLRP3 inflammasome assembly inhibitor. JT002 reduces NLRP3-dependent proinflammatory cytokine (such as IL-1β, IL-1α, IL-18) production and pyroptosis. JT002 blocks NLRP3 inflammasome complex formation. JT002 reduces airway hyperresponsiveness and airway neutrophilia in mice. JT002 can be used for the study of a variety of inflammatory diseases, such as Muckle-Wells syndrome (MWS). | ||||||||||||||||||||
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