1. MAPK/ERK Pathway
  2. JNK
  3. JTP10-△-TATi TFA

JTP10-△-TATi TFA 

Cat. No.: HY-P2246
Handling Instructions

JTP10-△-TATi TFA is a selective JNK2 peptide inhibitor, with an IC50 of 92 nM, exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

JTP10-△-TATi TFA Chemical Structure

JTP10-△-TATi TFA Chemical Structure

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Description

JTP10-△-TATi TFA is a selective JNK2 peptide inhibitor, with an IC50 of 92 nM, exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3[1].

IC50 & Target[1]

JNK2

92 nM (IC50)

JNK1

1.16 μM (IC50)

JNK3

1.2 μM (IC50)

In Vitro

JTP10-△-TATi TFA inhibits the migration of PyVMTjnk2+/+ cells and PyVMTjnk2-/- cells expressing GFP-JNK2α[1].

Molecular Weight

2833.28

Formula

C₁₂₀H₂₁₃F₃N₄₈O₂₈

Sequence

Ac-{Pro}{Lys}{Arg}{Pro}{Thr}{Thr}{Leu}{Asn}{Leu}{Phe}{Ahx}{Arg}{Arg}{Arg}{Gln}{Arg}{Arg}{Lys}{Lys}{Arg}{Gly}-amide

Sequence Shortening

Ac-PKRPTTLNLF-Ahx-RRRQRRKKRG-amide

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

JTP10-△-TATiJNKc-Jun N-terminal kinaseBreastcancerInhibitorinhibitorinhibit

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Product name:
JTP10-△-TATi TFA
Cat. No.:
HY-P2246
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