6-Aminonicotinic acid
Based on 1 Customer Validation
6-Aminonicotinic acid is an analog of Niacin (HY-B0143) and also a GABAA receptor agonist with a Ki value of 4.4 μM in rats. 6-Aminonicotinic acid binds to both native and recombinant GABAA receptors, is metabolized into non-functional pyridine nucleotide analogs to inhibit dehydrogenases, and suppresses the proliferation of T2 bacteriophages. 6-Aminonicotinic acid accumulates in specific bacterial cells in the form of pyridine nucleotide analog metabolites. 6-Aminonicotinic acid can be used in research related to neurological disorders such as anxiety, epilepsy and schizophrenia, and also serves as an intermediate in organic synthesis.
For research use only. We do not sell to patients.
- Purity: 99.56%
- CAS No.: 3167-49-5
- Formula: C6H6N2O2
- Molecular Weight:138.13
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
6-Aminonicotinic acid (6-ANAm) can be taken up by Escherichia coli W3899 NAm 11 cells, metabolized into multiple pyridine nucleotide analogs, and excreted in the form of 6-aminonicotinamide[1].
6-Aminonicotinic acid (compound 3) binds to native GABAA receptors in rat brain synaptic membranes, with a Ki value of 4.4 μM[2].
6-Aminonicotinic acid acts as a weak agonist at human α1β2γ2S GABAA receptors and human ρ1 GABAA receptors expressed in tsA201 cells[2].
6-Aminonicotinic acid (6-ANA) can be prepared via the electrocatalytic electrosynthesis of reducing 2-amino-5-bromopyridine on a silver cathode in a CO2-saturated solvent, with 2-aminopyridine as the major product[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3167-49-5
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Appearance Solid
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Molecular Weight 138.13
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Formula C6H6N2O2
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Color White to light yellow
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SMILES
O=C(O)C1=CN=C(N)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 2.5 mg/mL (18.10 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.2396 mL | 36.1978 mL | 72.3956 mL | 180.9889 mL |
| 5 mM | 1.4479 mL | 7.2396 mL | 14.4791 mL | 36.1978 mL | |
| 10 mM | 0.7240 mL | 3.6198 mL | 7.2396 mL | 18.0989 mL | |
| 15 mM | 0.4826 mL | 2.4132 mL | 4.8264 mL | 12.0659 mL |
6-Aminonicotinic acid Related Classifications
HY-W015793 Related Classifications
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